CDKN2A Antibody (phospho-S8)
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Catalog number
F48749-0.08ML
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Price
Please ask
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Size
0.08 ml
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Category
Antibody
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Concentration
In 1X PBS, pH 7.4, with 0.09% sodium azide
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Form
Antigen affinity purified
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Conjugation
Unconjugated
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Clone
Polyclonal antibody
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Recognised antigen
CDKN2A (phospho-S8)
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Host animal
Rabbit (Oryctolagus cuniculus)
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Clonality
Polyclonal (rabbit origin)
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Species reactivity
Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applications
DB, ELISA
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Recommended dilutions
Dot blot: 1:500
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Notes
Titration of the phospho-CDKN2A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Intented use
This phospho-CDKN2A antibodyis to be used only for research purposes and not for diagnostics..
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Uniprot
P42771
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Purity
Antigen affinity
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Description
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
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Immunogen
This phospho-CDKN2A antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS8 of human CDKN2A.
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Storage
Aliquot the phospho-CDKN2A antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
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Properties
If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
RPS8, PSMC5, CDKN2A-DT, CDKN2A
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Short name
Anti-CDKN2A (phospho-S8)
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Rabbit Ig
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Alternative name
Antibodies to CDKN2A (phospho-S8)
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Alternative technique
antibodies
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Alternative to gene target
cyclin-dependent kinase inhibitor 2A, ARF and CDK4I and CDKN2 and CMM2 and INK4 and INK4A and MLM and MTS-1 and MTS1 and P14 and P14ARF and P16 and P16-INK4A and P16INK4 and P16INK4A and P19 and P19ARF and TP16, CDKN2A and IDBG-54547 and ENSG00000147889 and 1029, MDM2/MDM4 family protein binding, nuclei, CDKN2A and IDBG-630043 and ENSBTAG00000034220 and 616369
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Gene info
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Identity
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Gene
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Long gene name
ribosomal protein S8
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Synonyms
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GenBank acession
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Locus
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Discovery year
1992-07-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNA protein coding host genes
- S ribosomal proteins
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VEGA ID
Gene info
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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