P-Glycoprotein (ABCB1) Antibody

• Catalog number
  F49437-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  P-Glycoprotein (ABCB1)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the P-Glycoprotein antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This P-Glycoprotein antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P08183
• Purity
  Purified
• Description
  The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
• Immunogen
  A portion of amino acids 647-677 from the human protein was used as the immunogen for this P-Glycoprotein antibody.
• Storage
  Aliquot the P-Glycoprotein antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  P-Glycoprotein   ABCB1  
• Gene symbol
  ABCB1
• Short name
  Anti-P-Glycoprotein (ABCB1)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to P-Glycoprotein (ABCB1)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40
• Gene
  ABCB1
• Long gene name
  ATP binding cassette subfamily B member 1
• Synonyms gene
  • PGY1
  • MDR1
  • CLCS
• Synonyms gene name
  • colchicin sensitivity
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1
• Synonyms
  • P-gp
  • CD243
  • GP170
  • ABC20
  • p-170
• Synonyms name
  • multidrug resistance protein 1
• GenBank acession
  • M14758
• Locus
  7q21.12
• Discovery year
  1986-01-01
• Entrez gene record
  5243
• Pubmed identfication
  • 3027054
• RefSeq identity
  • NM_000927
• Classification
  • ATP binding cassette subfamily B
  • CD molecules
• VEGA ID
  OTTHUMG00000023393

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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