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Orexin receptor 1 2 Antibody Conjugated

Orexin receptor 1 2 Antibody Conjugated is available 7 times from Bioss primary conjugated antibodies labs

bs-1095R-Biotin | Orexin receptor 1+2 Antibody, Biotin Conjugated size: 0.1ml | 381.95 USD

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bs-1095R-Cy3 | Orexin receptor 1+2 Antibody, Cy3 Conjugated size: 0.1ml | 401.45 USD

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bs-1095R-Cy5 | Orexin receptor 1+2 Antibody, Cy5 Conjugated size: 0.1ml | 401.45 USD

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bs-1095R-Cy5.5 | Orexin receptor 1+2 Antibody, Cy5.5 Conjugated size: 0.1ml | 401.45 USD

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bs-1095R-Cy7 | Orexin receptor 1+2 Antibody, Cy7 Conjugated size: 0.1ml | 401.45 USD

Long name Orexin receptor 1+2 Polyclonal Antibody, Cy7 Conjugated
Conjugation Cy7
Tested applications IF(IHC-P)
Recommended dilutions IF(IHC-P)(1:50-200)
Storage conditions Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
Excitation Emission 743nm/767nm
Properties If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Conjugated These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
Additional conjugation Cy7
Description The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
French translation anticorps
Short name Orexin receptor 1+2 Antibody, Conjugated
Technique Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
Label Cy7
Alternative name Orexin receptor 1+2 (Antibody to), cyanine 7 coupled
MeSH Data
Concept
Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Additional information
PubMedObservational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Observational study of gene-disease association. (HuGE Navigator)
GDNF variants associated with the apnea-hypopnea index as a continuous trait, and OSA as a dichotomous trait in European Americans
Observational study of gene-disease association. (HuGE Navigator)
This study describes the intracellular signalling pathways involved in OX2R-mediated ERK(1/2) and p38 MAPK activation.
Both sporadic narcoleptic dogs and human narcolepsy-cataplexy subjects showed a significant decrease in hcrtR1 expression, while declines in hcrtR2 expression were not significant in these cases.
Data demonstrated that hOX2R expression is regulated by a complex involving a proximal PKA/PKC-regulated promoter and a distal promoter regulating tissue-specific expression of alternative transcripts which in turn regulate receptor levels.
Results show that the N-terminal regions of orexin receptor are most important, and the exchange of the area from the C-terminal part of the transmembrane helix 2 to the transmembrane helix 4 is enough to lead to a change of the receptor's ligand profile.
Expression of the OX2R protein was detected in normal endometrial epithelia, whereas it was frequently lacking in endometrial endometrioid carcinoma.
The study determined structures of OX1R bound to the OX1R-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution and explored mechanisms of antagonist the subtype selectivity between OX1R and OX2R.

bs-1095R-FITC | Orexin receptor 1+2 Antibody, FITC Conjugated size: 0.1ml | 381.95 USD

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bs-1095R-HRP | Orexin receptor 1+2 Antibody, HRP Conjugated size: 0.1ml | 401.45 USD

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Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Target Antigen Orexin receptor 1+2
Specificity This is a highly specific antibody against Orexin receptor 1+2.
Modification Unmodified
Modification site None
Clonality Polyclonal
Clone Polyclonal antibody
Concentration 1ug per 1ul
Immunogen_range 364-414/444
Subcellular location Cytoplasm
Source KLH conjugated synthetic peptide derived from human Orexin receptor 1
Gene ID number 3062
Swiss Prot O43614
Crossreactivity Human, Mouse, Rat
Crossreactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Antigen background The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
Purification method This antibody was purified via Protein A.
Synonyms OX2R; Orexin receptor type 2; Ox-2-R; Ox2-R; Hypocretin receptor type 2; HCRTR2
Alternative technique antibodies
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