Nutlin-3, p53/mdm2 inhibitor

• Catalog number
  SIH-344-25MG
• Price
  Please ask
• Size
  25 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  548472-68-0
• Description
  p53/mdm2 inhibitor
• Molecular weight
  581,9 g/mol
• Primary research fields
  Cancer, Apoptosis, Cancer Growth Inhibitors, p53/mdm2 Inhibitors
• Other name
  (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5- dihydro-imidazole -1-carbonyl]-piperazin-2-one
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C30H30Cl2N4O4
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble in 100 mM DMSO and Ethanol
• Physical appearance
  Yellow solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
• PubChem number
  216345
• Scientific context
  MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
• Bibliography
  1. Vassilev et al (2004) Science 303: 844.
• Release date
  6-Jun-2012
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Nutlin-3 (SIH-344), a p53/mdm2 inhibitor. CAS #: 548472-68-0. Molecular Formula: C30H30Cl2N4O4. Molecular Weight: 581.9 g/mol. Chemical structure of Nutlin-3, a p53/mdm2 inhibitor (SIH-344). CAS # 548472-68-0. Molecular Formula: C30H30Cl2N4O4.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.025
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Nutlin-3   p53/mdm2   inhibitor  
• Short name
  Nutlin-3, p53/mdm2 inhibitor
• Alternative name
  Nutlin-3, p53/mdm2 suppressor

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