NUMBL Antibody, Biotin Conjugated
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Catalog numberbs-11974R-Biotin
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PricePlease ask
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Size0.1ml
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Long nameNUMBL Polyclonal Antibody, Biotin Conjugated
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CategoryConjugated Primary Antibodies
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ConjugationBiotin
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target AntigenNUMBL
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SpecificityThis is a highly specific antibody against NUMBL.
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ModificationUnmodified
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Modification siteNone
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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SourceKLH conjugated synthetic peptide derived from human NUMBL
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Tested applicationsWB, IHC-P
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500)
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CrossreactivityHuman, Mouse, Rat
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Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Antigen backgroundIn Drosophila, neuronal cell fate decisions are directed by NUMB, a signaling adapter protein with two protein-protein interaction domains, namely a phosphotyrosine-binding domain and a proline-rich SH3-binding region (PRR). The mammalian NUMB homolog plays a role in the determination of cell fate during development and binds with a variety of proteins, including Eps15, LNX1 and Notch 1. NumbL (NUMB-like protein), also known as Numb-R, NBL, CAG3A, CTG3a, NUMBLIKE or TNRC23, is a 609 amino acid cytoplasmic protein that, like NUMB, is thought to play a role in cell fate. Expressed at high levels in developing brain tissue, NumbL contains one PID (phosphotyrosine interaction domain) and plays an important role in neuronal differentiation, possibly associating with Eps15 and Notch 1. In mice, deletion of the NumbL gene is associated with early embryonic death, suggesting an essential role for NumbL in early development.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
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Excitation EmissionN/A
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SynonymsCAG 3A; CAG3A; CTG 3a; CTG3a; NBL; NUMB Drosophilia Homolog Like; Numb homolog Drosophila like; Numb homolog like; Numb like protein; NUMB R; Numb-like protein; Numb-R; Numb-related protein; NUMBL; NUMBL_HUMAN; NUMBR; TNRC 23; TNRC23.
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PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
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Additional conjugationBiotinylated
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French translationanticorps
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Gene target
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Gene symbolNUMBL
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Short nameAnti-NUMBL
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TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
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IsotypeImmunoglobulin G (IgG)
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LabelBiotin
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Alternative nameAnti-NUMBL PAb Biotin
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Alternative techniqueantibodies
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Alternative to gene targetnumb homolog (Drosophila)-like, CAG3A and CTG3a and NBL and NUMB-R and NUMBLIKE and NUMBR and TNRC23, NUMBL and IDBG-52025 and ENSG00000105245 and 9253, protein binding, Cytoplasm, Numbl and IDBG-160322 and ENSMUSG00000063160 and 18223, NUMBL and IDBG-638153 and ENSBTAG00000019461 and 510973
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Gene info
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Identity
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Gene
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Long gene nameNUMB like endocytic adaptor protein
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Synonyms gene name
- numb (Drosophila) homolog-like
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-03-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data