NPC 15437, PKC kinase inhibitor

  • Catalog number
    SIH-464-5MG
  • Price
    Please ask
  • Size
    5 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    141774-20-1
  • Description
    PKC kinase inhibitor
  • Molecular weight
    511,6 g/mol
  • Primary research fields
    Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
  • Other name
    (S)-2,6-diamino-N-{[1'-(1''-oxotridecyl)-2'-piperidinyl]methyl}hexanamide . 2HCl
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C25H52Cl2N4O2
  • Origin
    Synthetic
  • Purity pourcentage
    ≥98% (HPLC)
  • Soluble in
    Soluble in water, DMSO or methanol
  • Physical appearance
    White to off-white solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
  • PubChem number
    16219723
  • Scientific context
    NPC 15437 is selective inhibitor of protein kinase C (PKC). Specifically, it interacts with regulatory domain at residues 12-42.
  • Bibliography
    1. Sullivan J.P., Connor J.R., Shearer B.G., & Burch R.M. (1991) Agents and Actions. 34(1-2): 142–144. 2. Sullivan J.P., Connor J.R., Tiffany C., Shearer B.G., & Burch R.M. (1991) FEBS Letters. 285(1): 120–123.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of NPC 15437 (SIH-464), a PKC kinase inhibitor. CAS #: 141774-20-1. Molecular Formula: C25H52Cl2N4O2. Molecular Weight: 511.6 g/mol. Chemical structure of NPC 15437, a PKC kinase inhibitor (SIH-464). CAS # 141774-20-1. Molecular Formula: C25H52Cl2N4O2.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.005
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
    NPC   15437   PKC   kinase   inhibitor  
  • Gene symbol
    PRKCH, PRKD1, PRRT2, PRKDC
  • Short name
    NPC 15437, PKC kinase inhibitor
  • Alternative name
    NPC 15437, PKC phosphorylation catalyst suppressor
Gene info
Gene info
Gene info
Gene info
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