NPC 15437, PKC kinase inhibitor
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Catalog numberSIH-464-5MG
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PricePlease ask
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Size5 mg
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Stock availabilitIn StockIn Stock
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CAS number141774-20-1
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DescriptionPKC kinase inhibitor
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Molecular weight511,6 g/mol
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Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name(S)-2,6-diamino-N-{[1'-(1''-oxotridecyl)-2'-piperidinyl]methyl}hexanamide . 2HCl
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC25H52Cl2N4O2
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OriginSynthetic
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Purity pourcentage≥98% (HPLC)
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Soluble inSoluble in water, DMSO or methanol
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Physical appearanceWhite to off-white solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number16219723
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Scientific contextNPC 15437 is selective inhibitor of protein kinase C (PKC). Specifically, it interacts with regulatory domain at residues 12-42.
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Bibliography1. Sullivan J.P., Connor J.R., Shearer B.G., & Burch R.M. (1991) Agents and Actions. 34(1-2): 142–144. 2. Sullivan J.P., Connor J.R., Tiffany C., Shearer B.G., & Burch R.M. (1991) FEBS Letters. 285(1): 120–123.
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Release date1-Oct-2014
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of NPC 15437 (SIH-464), a PKC kinase inhibitor. CAS #: 141774-20-1. Molecular Formula: C25H52Cl2N4O2. Molecular Weight: 511.6 g/mol. Chemical structure of NPC 15437, a PKC kinase inhibitor (SIH-464). CAS # 141774-20-1. Molecular Formula: C25H52Cl2N4O2.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.005
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolPRKCH, PRKD1, PRRT2, PRKDC
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Short nameNPC 15437, PKC kinase inhibitor
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Alternative nameNPC 15437, PKC phosphorylation catalyst suppressor
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Gene info
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Identity
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Gene
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Long gene nameprotein kinase C eta
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Synonyms gene
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Synonyms gene name
- protein kinase C, eta
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-06-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C2 domain containing protein kinases
- AGC family kinases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprotein kinase D1
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Synonyms gene
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Synonyms gene name
- protein kinase C, mu
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Synonyms
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Locus
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Discovery year1994-05-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Pleckstrin homology domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameproline rich transmembrane protein 2
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Synonyms gene
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Synonyms gene name
- infantile convulsions and paroxysmal choreoathetosis
- dystonia 10
- proline-rich transmembrane protein 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-11-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- interferon induced transmembrane protein domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprotein kinase, DNA-activated, catalytic subunit
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Synonyms gene
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Synonyms gene name
- protein kinase, DNA-activated, catalytic polypeptide
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Synonyms
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Synonyms name
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Locus
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Discovery year1993-11-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Armadillo like helical domain containing
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VEGA ID
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Locus Specific Databases