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Alternative_name
Albamycin; Cathomycin sodium; NSC-2382
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Description
Novobiocin is a coumarin antibiotic isolated from Streptomyces species, that inhibits the ATPase activity of DNA gyrase. Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit. In addition to permitting relaxation of negative supercoils, novobiocin has been used to generate positively supercoiled DNA. It has also been shown to inhibit the chaperone activity of Hsp90 as well as acting as an inhibitor of DNA Topoisomerase II.
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CAS Number
1476-53-5
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Structure Available
Yes
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Molecular Formula
C₃₁H₃₅N₂NaO₁₁
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Molecular Weight
634.61
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Cell Permeable
Yes
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Purity
≥90%
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Solubilities
H₂O (~50 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
An inhibitor of bacterial DNA gyrase
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Storage Condition
+4°C
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Shipping Condition
Gel Pack
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Shelf Life
36 months
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MDL Number
MFCD00066541
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PubChem CID
54730021
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SMILES
CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]
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InChi
InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q;+1/p-1
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InChi Key
WWPRGAYLRGSOSU-UHFFFAOYSA-M
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MSDS Available
Yes
