RTN4 Antibody / Reticulon 4

• Catalog number
  F53834-0.05ML
• Price
  Please ask
• Size
  0.05 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  RTN4 / Reticulon 4
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 1:1000-2000
• Intented use
  This RTN4 antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  57142
• Uniprot
  Q9NQC3
• Purity
  Antigen affinity
• Description
  Reticulon-4 is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
• Immunogen
  A portion of amino acids 28-58 from the human protein was used as the immunogen for the RTN4 antibody.
• Storage
  Aliquot the RTN4 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RTN4   Reticulon  
• Gene symbol
  RTN4
• Short name
  Anti- RTN4 / Reticulon 4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to RTN4 / Reticulon 4
• Alternative technique
  antibodies
• Alternative to gene target
  reticulon 4, RTN4 and IDBG-52161 and ENSG00000115310 and 57142, poly(A) RNA binding, nuclei, Rtn4 and IDBG-157815 and ENSMUSG00000020458 and 68585, RTN4 and IDBG-633945 and ENSBTAG00000011104 and 359718

Gene info

• Identity
  HGNC:14085
• Gene
  RTN4
• Long gene name
  reticulon 4
• Synonyms
  • NSP-CL
  • KIAA0886
  • NOGO
  • ASY
• GenBank acession
  • AF087901
• Locus
  2p16.1
• Discovery year
  2000-11-28
• Entrez gene record
  57142
• Pubmed identfication
  • 10667797
  • 10773680
• VEGA ID
  OTTHUMG00000129337

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products