Human CellExp™ ICOSLG /B7-H2 /CD275, Fc Tag, Human Recombinant

• Catalog number
  P1384-50
• Price
  Please ask
• Size
  50 µg

• Synonyms
  ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, ICOS ligand
• Alternative_names
  ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, ICOS ligand
• Description
  Ligand for the T-cell-specific cell surface receptor ICOS
• Source
  HEK 293 cells
• Purity by SDS PAGE
  >95% as determined by SDS-PAGE.
• Endotoxin Level
  Less than 1.0 EU per ug by the LAL method.
• Activity Specifications test method
  Immobilized Human ICOS (C136S, C137S) at 5 ug/mL (100 uL/well) can bind Human B7-H2, Fc Tag with a linear range of 0.3-5 ng/mL
• Molecular Weight
  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 53.1 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized powder
• Physical form description
  Lyophilized powder
• Reconstitution Instructions
  Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. It is recommended to store at -20°C.
• Background Information
  ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
• Amino acid sequence
  AA Asp 19 - Ser 258
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   ICOSLG   B7-H2   CD275   Tag  
• Gene symbol
  ICOSLG, NCAPH2, TUBA3D, HHLA2, RNY4P2, LRRC23, NME2, PCDHGB7, CFB, NCR3LG1
• Short name
  CellExp™ ICOSLG /B7-H2 /CD275, Fc Tag, Recombinant
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  Fc Tag
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ inducible T-cellular co-stimulator ligand /B7-H2 /CD275, fragment c detection labelled, H. sapiens Rec.
• Alternative technique
  rec
• Alternative to gene target
  inducible T-cell co-stimulator ligand, ICOSLG and IDBG-5107 and ENSG00000160223 and 102723996,23308, protein binding, Plasma membranes, Icosl and IDBG-168471 and ENSMUSG00000000732 and 50723, ICOSLG and IDBG-639662 and ENSBTAG00000014880 and 507857

Gene info

• Identity
  HGNC:17087
• Gene
  ICOSLG
• Long gene name
  inducible T cell costimulator ligand
• Synonyms gene
  • ICOSL
• Synonyms gene name
  • inducible T-cell costimulator ligand
• Synonyms
  • KIAA0653
  • GL50
  • B7-H2
  • B7RP-1
  • B7H2
  • B7RP1
  • ICOS-L
  • CD275
  • B7h
• Synonyms name
  • B7-related protein 1
  • B7 homologue 2
  • B7 homolog 2
• GenBank acession
  • AB014553
• Locus
  21q22.3
• Discovery year
  2003-12-12
• Entrez gene record
  23308
• Pubmed identfication
  • 9734811
  • 11007762
• RefSeq identity
  • NM_015259
• Classification
  • B7 family
  • CD molecules
  • Receptor ligands
  • C2-set domain containing
  • V-set domain containing
• VEGA ID
  OTTHUMG00000086920

Gene info

• Identity
  HGNC:25071
• Gene
  NCAPH2
• Long gene name
  non-SMC condensin II complex subunit H2
• Synonyms gene name
  • non-SMC condensin II complex, subunit H2
• Synonyms
  • 384D8-2
  • hCAP-H2
  • CAP-H2
• Synonyms name
  • kleisin beta
  • CAP-H2 subunit of the condensin II complex
• GenBank acession
  • BC001937
• Locus
  22q13.33
• Discovery year
  2006-09-04
• Entrez gene record
  29781
• Pubmed identfication
  • 10493829
• RefSeq identity
  • NM_152299
• Classification
  • Condensin II subunits
• VEGA ID
  OTTHUMG00000150205

Gene info

• Identity
  HGNC:24071
• Gene
  TUBA3D
• Long gene name
  tubulin alpha 3d
• Synonyms
  • H2-ALPHA
• Synonyms name
  • alpha-tubulin isotype H2-alpha
• GenBank acession
  • K03460
• Locus
  2q21.1
• Discovery year
  2007-02-12
• Entrez gene record
  113457
• Pubmed identfication
  • 3785200
• RefSeq identity
  • NM_080386
• Classification
  • Tubulins
• VEGA ID
  OTTHUMG00000153600

Gene info

• Identity
  HGNC:4905
• Gene
  HHLA2
• Long gene name
  HERV-H LTR-associating 2
• Synonyms
  • B7H7
  • B7-H5
  • B7y
  • B7-H7
• GenBank acession
  • AF126162
• Locus
  3q13.13
• Discovery year
  1999-09-07
• Entrez gene record
  11148
• Pubmed identfication
  • 10444326
  • 23784006
  • 22488247
• RefSeq identity
  • NM_007072
• Classification
  • C1-set domain containing
  • V-set domain containing
  • B7 family
• VEGA ID
  OTTHUMG00000159224

Gene info

• Identity
  HGNC:10246
• Gene
  RNY4P2
• Long gene name
  RNY4 pseudogene 2
• Synonyms gene name
  • RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
  • RNA, Ro-associated Y4 pseudogene 2
• Synonyms
  • hY4.B7
• GenBank acession
  • M77130
• Locus
  17q21.31
• Discovery year
  1993-08-25
• Entrez gene record
  6088
• RefSeq identity
  • NG_005037

Gene info

• Identity
  HGNC:19138
• Gene
  LRRC23
• Long gene name
  leucine rich repeat containing 23
• Synonyms
  • B7
  • LRPB7
• GenBank acession
  • BC014450
• Locus
  12p13.31
• Discovery year
  2006-01-24
• Entrez gene record
  10233
• Pubmed identfication
  • 11830501
  • 11826754
• RefSeq identity
  • NM_006992
• VEGA ID
  OTTHUMG00000156668

Gene info

• Identity
  HGNC:7850
• Gene
  NME2
• Long gene name
  NME/NM23 nucleoside diphosphate kinase 2
• Synonyms gene name
  • non-metastatic cells 2, protein (NM23B) expressed in
• Synonyms
  • NM23-H2
  • NDPKB
• GenBank acession
  • X58965
• Locus
  17q21.33
• Discovery year
  1991-07-26
• Entrez gene record
  4831
• Pubmed identfication
  • 1988104
  • 19852809
• RefSeq identity
  • NM_002512
• Classification
  • NME/NM23 family
• VEGA ID
  OTTHUMG00000154062

Gene info

• Identity
  HGNC:8714
• Gene
  PCDHGB7
• Long gene name
  protocadherin gamma subfamily B, 7
• Synonyms
  • ME6
  • PCDH-GAMMA-B7
• Synonyms name
  • cadherin ME6
• GenBank acession
  • AF152523
• Locus
  5q31.3
• Discovery year
  2000-06-28
• Entrez gene record
  56099
• Pubmed identfication
  • 10380929
• RefSeq identity
  • NM_018927
• Classification
  • Clustered protocadherins
• VEGA ID
  OTTHUMG00000164054

Gene info

• Identity
  HGNC:1037
• Gene
  CFB
• Long gene name
  complement factor B
• Synonyms gene
  • BFD
  • BF
• Synonyms gene name
  • B-factor, properdin
• Synonyms
  • H2-Bf
• GenBank acession
  • L15702
• Locus
  6p21.33
• Discovery year
  1986-01-01
• Entrez gene record
  629
• RefSeq identity
  • NM_001710
• Classification
  • Complement system activation components
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000031198
• Locus Specific Databases
  • LRG_136

Gene info

• Identity
  HGNC:42400
• Gene
  NCR3LG1
• Long gene name
  natural killer cell cytotoxicity receptor 3 ligand 1
• Synonyms
  • DKFZp686O24166
  • B7-H6
• Synonyms name
  • B7 homolog 6
• Locus
  11p15.1
• Discovery year
  2012-04-12
• Entrez gene record
  374383
• Pubmed identfication
  • 19528259
• RefSeq identity
  • NM_001202439
• Classification
  • Receptor ligands
  • C1-set domain containing
  • B7 family
• VEGA ID
  OTTHUMG00000165913

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products