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Alternative_name
(6R,7R)-3-[2-(2,4-dinitrophenyl)ethenyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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Description
Nitrocefin is the chromogenic cephalosporin that acts as an excellent β-lactamase substrate. It exhibits a rapid distinctive color change from yellow (max at pH 7.0 = 390 nm) to red (max at pH 7.0 = 486 nm) as the amide bond in the beta-lactam ring is hydrolyzed by a β-lactamase. It is sensitive to hydrolysis by all known lactamases produced by Gram-positive and Gram-negative bacteria.
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CAS Number
41906-86-9
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₁H₁₆N₄O₈S₂
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Molecular Weight
516.5
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Cell Permeable
No
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Purity
≥95% by UV
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Solubilities
DMSO
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Handling
Protect from light and air
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Tag Line
A chromogenic β-lactamase substrate
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Storage Condition
-20 ̊C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00864896
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PubChem CID
6436140
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SMILES
C1C(=C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CS3)C(=O)O)C=CC4=C(C=C(C=C4)[N+](=O)[O-])[N+](=O)[O-]
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InChi
InChI=1S/C21H16N4O8S2/c26-16(9-14-2-1-7-34-14)22-17-19(27)23-18(21(28)29)12(10-35-20(17)23)4-3-11-5-6-13(24(30)31)8-15(11)25(32)33/h1-8,17,20H,9-10H2,(H,22,26)(H,28,29)/b4-3+/t17-,20-/m1/s1
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InChi Key
LHNIIDJCEODSHA-OQRUQETBSA-N
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MSDS Available
Yes