Niclosamide, Autophagy inducer

• Catalog number
  SIH-406-1G
• Price
  Please ask
• Size
  1 g

• Stock availabilitIn Stock
  In Stock
• CAS number
  50-65-7
• Description
  Autophagy inducer
• Molecular weight
  327,12 g/mol
• Primary research fields
  Cancer, Autophagy
• Other name
  5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
• Product category
  Small Molecules
• Product type
  Inducer
• Chemical formula
  C13H8Cl2N2O4
• Origin
  Synthetic
• Purity pourcentage
  >98% (TLC); NMR (Conforms)
• Soluble in
  Soluble to 25 mM in ethanol and to 10 mM in DMSO
• Physical appearance
  Pale yellow solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  4477
• Scientific context
  Niclosamide is part of the anthelmintics drug class, which are used to treat tapeworm infections in humans. Niclosamide has been shown to selectively inhibit the Stat-3 signalling pathway, specifically by inhibiting its activation, nuclear translocation and transcriptional activity. It has also been reported that Niclosamide inhibits mTORC1, thereby inducing autophagy and increasing the formation of autophagosomes.
• Bibliography
  1. Pan J.X., et al. (2012) Chin J Cancer. 31(4): 178-84.
• Release date
  31-Mar-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Niclosamide (SIH-406), a Autophagy inducer. CAS #: 50-65-7. Molecular Formula: C13H8Cl2N2O4. Molecular Weight: 327.12 g/mol. Chemical structure of Niclosamide, a Autophagy inducer (SIH-406). CAS # 50-65-7. Molecular Formula: C13H8Cl2N2O4.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  1
• Other related products

• Gene target
  Niclosamide   Autophagy   inducer  
• Short name
  Niclosamide, Autophagy inducer
• Alternative name
  Niclosamide, Autophagy inducer

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