Nicardipine HCl, L-type Ca channel blocker
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Catalog number
SIH-313-250MG
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Price
Please ask
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Size
250 mg
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Stock availabilitIn Stock
In Stock
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CAS number
54527-84-3
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Description
L-type Ca channel blocker
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Molecular weight
515,99 g/mol
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Primary research fields
Neuroscience, Ion Channels, Calcium Channels, Voltage-Gated Calcium Channels
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Other name
2-[Benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C26H29N3O6•HCl
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in DMSO (1 mg/ml), ethanol:water 25:75-70:30, propylene glycol, or methanol; slightly soluble in acetone, 100% ethanol, chloroform and water.
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Physical appearance
Yellow solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45- In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) Risk Phrases: R23/24/25- Toxic by inhalation, if swallowed and in contact with skin. Hazard Phrases: H301-H311-H331 Precautionary Phrases: P261-P280-P301 + P310-P311
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PubChem number
41114
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Scientific context
Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hyptertension and Raynaud’s phenomenon. Its mechanism of acion is to inhibit the transmembrane influx of calcium ions into the cardiac muscle and smooth muscle without changing the serum calcium concentrations.
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Bibliography
1. Huang R.I., et al. (2006) Catheter Cardiovasc Interv. 68(5): 671-676.
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Release date
8-Apr-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Nicardipine HCl (SIH-313), a L-type Ca channel blocker. CAS #: 54527-84-3. Molecular Formula: C26H29N3O6 · HCl. Molecular Weight: 515.99 g/mol. Chemical structure of Nicardipine HCl, a L-type Ca channel blocker (SIH-313). CAS # 54527-84-3. Molecular Formula: C26H29N3O6 · HCl.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.25
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Gene target
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Short name
Nicardipine HCl, L- Ca channel blocker
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Alternative name
Nicardipine HCl, L-classification Ca channel blocker
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