NFKB p65 Ser276 Antibody Conjugated

NFKB p65 Ser276 Antibody Conjugated is available 7 times from Bioss primary conjugated antibodies labs

  • Category
    Conjugated Primary Antibodies
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    NFKB p65 Ser276
  • Specificity
    This is a highly specific antibody against NFKB p65 Ser276.
  • Modification
  • Modification site
  • Clonality
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Immunogen_range
  • Source
    KLH conjugated synthetic phosphopeptide derived from human NFKBp65 around the phosphorylation site of Ser276
  • Gene ID number
  • Swiss Prot
  • Crossreactivity
    Human, Mouse, Rat
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p15, NFKB1/p5, REL and NFKB2/p52 and the heterodimeric p65-p5 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p5 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1.
  • Purification method
    This antibody was purified via Protein A.
  • Synonyms
    p65; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; RELA

bs-3543R-Biotin | NFKB p65(Ser276) Antibody, Biotin Conjugatedsize: 0.1ml | 430.54 USD

  • Long name
    NFKB p65(Ser276) Polyclonal Antibody, Biotin Conjugated
  • Conjugation
  • Tested applications
    WB, IHC-P
  • Recommended dilutions
    WB(1:100-1000), IHC-P(1:100-500)
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
  • Additional conjugation
  • Gene
    NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory
  • French translation
  • Short name
    NFKB p65(Ser276) Antibody, Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
  • Alternative name
    NFKB p65(Ser276) (Antibody to), biotinilated coupled
1. Gene info
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
Additional information
Product images

bs-3543R-Cy3 | NFKB p65(Ser276) Antibody, Cy3 Conjugatedsize: 0.1ml | 452.68 USD

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bs-3543R-Cy5 | NFKB p65(Ser276) Antibody, Cy5 Conjugatedsize: 0.1ml | 452.68 USD

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bs-3543R-Cy5.5 | NFKB p65(Ser276) Antibody, Cy5.5 Conjugatedsize: 0.1ml | 452.68 USD

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bs-3543R-Cy7 | NFKB p65(Ser276) Antibody, Cy7 Conjugatedsize: 0.1ml | 452.68 USD

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bs-3543R-FITC | NFKB p65(Ser276) Antibody, FITC Conjugatedsize: 0.1ml | 430.54 USD

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bs-3543R-HRP | NFKB p65(Ser276) Antibody, HRP Conjugatedsize: 0.1ml | 452.68 USD

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NFKB p65 Ser276 Antibody Conjugated -
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