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Target antigen
NFkB p100/p52
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
rat
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Analyses
WB,IHC-P
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Immunogen
E.coli-derived human NFkB p100/p52 recombinant protein (Position: M1-R340). Human NFkB p100/p52 shares 96% amino acid (aa) sequence identity with mouse NFkB p100/p52.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the NFkB p100/p52 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The NFkB p100/p52 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
NFKB2, also known as nuclear factor NF-kappa-B p100 subunit, is a protein that in humans is encoded by the NFKB2 gene. It is mapped to 10q24.32. This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFKB). NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner.
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Related articles
1. Schmid RM, Perkins ND, Duckett CS, Andrews PC, Nabel GJ (Sep 1991). "Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65". Nature 352 (6337): 733–6. 2. Basak, S., Kim, H., Kearns, J. D., Tergaonkar, V., O'Dea, E., Werner, S. L., Benedict, C. A., Ware, C. F., Ghosh, G., Verma, I. M., Hoffmann, A. A fourth I-kappa-B protein within the NF-kappa-B signaling module. Cell 128: 369-381, 2007. 3. "Entrez Gene: NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)"
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Gene Name
NFKB2
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Protein Name
Nuclear factor NF-kappa-B p100 subunit
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Gene Full Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
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Synonyms
DNA binding factor KBF2 antibody|DNA-binding factor KBF2 antibody|H2TF1 antibody|Lymphocyte translocation chromosome 10 antibody|Lymphocyte translocation chromosome 10 protein antibody|Lyt 10 antibody|Lyt10 antibody|NF kB2 antibody|NFKB2 antibody|NFKB2_HUMAN antibody|Nuclear factor NF kappa B p100 subunit antibody|Nuclear factor NF kappa B p52 subunit antibody|Nuclear factor NF-kappa-B p52 subunit antibody|Nuclear factor of kappa light chain gene enhancer in B cells 2 antibody|Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 antibody|Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 antibody|Oncogene Lyt 10 antibody|Oncogene Lyt-10 antibody|p105 antibody|p49/p100 antibody
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Uniprot ID
Q00653
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Entrez GeneID
4791
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Gene
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory
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French translation
anticorps
