NFAT5 (Ser1197) Antibody
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Catalog numberbs-9474R
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PricePlease ask
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Size0.1ml
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Long nameNFAT5 (Ser1197) Primary Polyclonal Antibody
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Also known asNFAT5 (Ser1197) PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenNFAT5 Ser1197
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SpecificityThis is a highly specific antibody against NFAT5 Ser1197.
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Modification sPhosphorylation
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Modification site sSer1197
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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SourceKLH conjugated synthetic phosphopeptide derived from human NFAT5 around the phosphorylation site of Ser1197
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Gene ID number10725
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenMembers of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesNFAT5 phospho S1197; p-NFAT5phospho S1197; Glutamine rich protein H65; KIAA0827; NF AT5; NF-AT5; NFAT 5; NFAT L1; NFAT like protein 1; NFAT5; NFAT5_HUMAN; NFATL 1; NFATL1; NFATZ; Nuclear factor of activated T cells 5; Nuclear factor of activated T cells 5 tonicity responsive; Nuclear factor of activated T cells; Nuclear factor of activated T-cells 5; OREBP; Osmotic response element binding protein; T cell transcription factor NFAT 5; T cell transcription factor NFAT5; T-cell transcription factor NFAT5; TonE binding protein; TonE-binding protein ; TonEBP; Tonicity responsive enhancer binding protein; Tonicity-responsive enhancer-binding protein.
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolNFAT5
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Short nameAnti-NFAT5 Ser1197
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameNFAT5 (Ser1197) Polyclonal Antibody
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Alternative techniqueantibodies
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Alternative to gene targetnuclear factor of activated T-cells 5, tonicity-responsive, NF-AT5 and NFATL1 and NFATZ and OREBP and TONEBP, NFAT5 and IDBG-39265 and ENSG00000102908 and 10725, protein binding, nuclei, Nfat5 and IDBG-190689 and ENSMUSG00000003847 and 54446, NFAT5 and IDBG-634541 and ENSBTAG00000013412 and 538523
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Gene info
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Identity
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Gene
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Long gene namenuclear factor of activated T cells 5
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Synonyms gene name
- nuclear factor of activated T-cells 5, tonicity-responsive
- nuclear factor of activated T-cells 5
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-07-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- IPT domain containing
- Nuclear factors of activated T-cells
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data