Necrosulfonamide
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Catalog number9635-50
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PricePlease ask
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Size50 mg
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Alternative_name(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; NSA
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DescriptionNecrosulfonamide is a potent necroptosis inhibitor. It blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Unlike Necrostatin-1 (Cat. No. 1864), NSA does not inhibit the necrosis-induced RIP1 and RIP3 interactions.
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CAS Number1360614-48-7
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₈H₁₅N₅O₆S₂
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Molecular Weight461.47
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>5 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent necroptosis inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID1566236
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SMILESCOC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-]
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InChiInChI=1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+
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InChi KeyFNPPHVLYVGMZMZ-XBXARRHUSA-N
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MSDS AvailableYes
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Gene target
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Short nameNecrosulfonamide
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Alternative nameNecrosulfonamide
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