Necrosulfonamide

Necrosulfonamide is available 4 times from Biovision labs

9635-10 | Necrosulfonamidesize: 2X10 mg | 384.91 USD

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9635-50 | Necrosulfonamidesize: 50 mg | 549.07 USD

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9635-50 | Necrosulfonamide for cell activationsize: 50 mg | 456.24 USD

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9635-10 | Necrosulfonamide for cell activationsize: 10 mg | 160.76 USD

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  • Alternate Name/Synonyms
    (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; NSA
  • Appearance
    Yellow solid
  • Formulation
    N/A
  • CAS Number
    1360614-48-7
  • Peptide sequence
    N/A
  • Molecular Formula
    C₁₈H₁₅N₅O₆S₂
  • Molecular Weight
    461.47
  • Purity
    ≥98% by HPLC
  • Solubility/Reconstitution Instructions
    DMSO (>5 mg/ml)
  • Handling
    Protect from air and light
  • Tagline
    A potent necroptosis inhibitor
  • Storage Temp.
    -20°C
  • Shipping Conditions
    gel pack
  • Shelf Life
    36 months
  • MDL Number
    N/A
  • PubChem CID
    1566236
  • Category
    Biochemicals
  • Description
    Necrosulfonamide is a potent necroptosis inhibitor. It blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Unlike Necrostatin-1 (Cat. No. 1864), NSA does not inhibit the necrosis-induced RIP1 and RIP3 interactions. 
  • CAS number
    1360614-48-7
  • Molecular weight
    461.47
  • Other name
    (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; NSA
  • Molecular formula
    C₁₈H₁₅N₅O₆S₂
  • Physical appearance
    Yellow solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥98% by HPLC
  • Reconstitute instructions
    DMSO (>5 mg/ml)
  • Storage condition
    -20°C
  • Shipping condition
    gel pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from air and light
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