Native Porcine Dipeptidylpeptidase IV (Native Protein)

• Catalog number
  30 802 102
• Price
  Please ask
• Size
  100 mU/ 80 µl

• Protein type
  Native
• Protein subtype
  EC 3.4.14.5
• Protein family
  Cysteinproteinase
• Protein description
  Porcine DPPIV is a cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones (By similarity). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
• Research area interests
  Diseases associated with DPP4 include Hepatosplenic T-Cell Lymphoma and Nasopharyngitis. Among its related pathways are Transport to the Golgi and subsequent modification and Peptide hormone metabolism.
• Package form
  liquid
• Tested applications
  Screening of inhibitors; Characterization of structure and function;
• Other names
  DPPIV; Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2)
• Peptide sequence
  MKTPWKVLLGLLGIAALVTVITVPVVLLNKGTDDAAADSRRTYTLTDYLKSTFRVKFYTLQWISDHEYLYKQENNILLFNAEYGNSSIFLENSTFDELGYSTNDYSVSPDRQFILFEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNLSSQRITWTGKENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIVPPASVLIGDHYLCGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWISSVARQHIEISTTGWVGRFRPAEPHFTSDGNSFYKIISNEEGYKHICHFQTDKSNCTFITKGAWEVIGIEALTSDYLYYISNEHKGMPGGRNLYRIQLNDYTKVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLYTLHSSSSDKELRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSKKYPLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEYYDSVYTERYMGLPTPEDNLDYYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQLSKALVDAGVDFQTMWYTDEDHGIASNMAHQHIYTHMSHFLKQCFSLP
• Available target modification
  Yes
• Expression system
  Porcine Kidney
• Product Subtype
  full length
• Active form
  Yes
• Tag
  untagged
• Contents
  20 mM Tris-HCl pH 8.0, 5 mM CaCl2, 1 μM ZnCl2, 0.05% NaN3
• Protein purity
  >90%
• Molecular weight
  120 kDa
• UniProt number
  P22411
• Gene number
  397492
• Abbreviation
  DPP4
• Full name
  dipeptidyl peptidase 4
• Other desciption
  Native fully glycosylated Dipeptidypeptidase IV is purified from the porcine renal brush border of the proximal tubule.
• Purification
  Mentioned in the data sheet
• PubMed citations
  See the data sheet
• Warnings
  For Research Use only.
• Shipping conditions
  dry ice
• Storage condition
  Store at -70°C
• Technical datasheet
  Contact us to receive the datasheet
• Representative figure
• Other products

• Gene target
  Native   Dipeptidylpeptidase   Native   Protein  
• Short name
  Native Porcine Dipeptidylpeptidase IV (Native Protein)
• Species
  Sus scrofa (pig)
• Alternative name
  Native swine Dipeptidylpeptidase IV (Native Protein)

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