L-NAME hydrochloride

  • Catalog number
    2356-1000
  • Price
    Please ask
  • Size
    1 g
  • Alternative_name
    NG-Nitro-L-arginine methyl ester hydrochloride
  • Description
    A pro-drug of L- NG-Nitro-L-arginine (L-NOARG). Hydrolysis of the methyl ester of L-NAME by cellular esterases converts it into a fully functional L-NOARG that exhibits some selectivity for inhibition of neuronal and endothelial NOS isoforms (Ki values of 15 nM, 39 nM, and 4.4 µM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively). L-NAME inhibits cGMP formation in endothelial cells with an IC₅₀ of 3.1 µM (in the presence of 30 µM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC₅₀ of 0.54 µM.
  • CAS Number
    51298-62-5
  • Structure Available
    Yes
  • Peptide sequence
    H-Arg(NO2)-OMeHCl
  • Salt Form
    Yes
  • Molecular Formula
    C₇H₁₅N₅O₄.HCl
  • Molecular Weight
    269.69
  • Cell Permeable
    Yes
  • Purity
    ≥98%
  • Solubilities
    DMSO (~ 5 mg/ml) or H2O (~50 mg/ml)
  • Handling
    Protect from air and moisture
  • Tag Line
    A pro-drug of the NOS inhibitor L- NG-Nitro-L-arginine
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • MDL Number
    MFCD00039052
  • PubChem CID
    135193
  • SMILES
    COC(=O)C(CCCN=C(N)N[N+](=O)[O-])N.Cl
  • InChi
    InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
  • InChi Key
    QBNXAGZYLSRPJK-JEDNCBNOSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    CPT1A, POM121L2, L3MBTL2, CLDN10, RPL32P1, FABP1, COX7A2, NFIA, ATRN, ANP32E
  • Short name
    L-NAME hydrochloride
  • Alternative name
    L-NAME hydrochloride
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    POM121 transmembrane nucleoporin like 2
  • Synonyms gene name
    • POM121 membrane glycoprotein-like 2 (rat)
    • POM121 membrane glycoprotein-like 2
    • POM121 transmembrane nucleoporin-like 2
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-07-20
  • Entrez gene record
  • RefSeq identity
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
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