MTA1 Antibody

• Catalog number
  bs-1412R
• Price
  Please ask
• Size
  0.1ml

• Long name
  MTA1 Primary Polyclonal Antibody
• Also known as
  MTA1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  MTA1
• Specificity
  This is a highly specific antibody against MTA1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  650-700/715
• Subcellular location
  Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MTA1
• Gene ID number
  9112
• Swiss Prot
  Q13330
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Plays a role in the inflammatory responses, both as a target and as a component of the NF-kappa-B signaling and regulates a subset of proinflammatory cytokines such as IL1B, MIP2, and TNF. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Metastasis-associated protein MTA1; MTA1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MTA1  
• Gene symbol
  MTA1, MTA2
• Short name
  Anti-MTA1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  MTA1 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7410
• Gene
  MTA1
• Long gene name
  metastasis associated 1
• GenBank acession
  • U35113
• Locus
  14q32.33
• Discovery year
  1999-03-12
• Entrez gene record
  9112
• Pubmed identfication
  • 8083195
  • 7607577
• Classification
  • GATA zinc finger domain containing
  • NuRD complex subunits
  • Myb/SANT domain containing
• VEGA ID
  OTTHUMG00000150362

Gene info

• Identity
  HGNC:7411
• Gene
  MTA2
• Long gene name
  metastasis associated 1 family member 2
• Synonyms gene
  • MTA1L1
• Synonyms gene name
  • metastasis associated gene family, member 2
• Synonyms
  • MTA1-L1
• GenBank acession
  • AB016591
• Locus
  11q12.3
• Discovery year
  1999-05-17
• Entrez gene record
  9219
• Pubmed identfication
  • 9929979
• RefSeq identity
  • NM_004739
• Classification
  • GATA zinc finger domain containing
  • NuRD complex subunits
  • Myb/SANT domain containing
• VEGA ID
  OTTHUMG00000167684

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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