PlacentalAlkaline Phosphatase (PLAP) (Germ Cell Tumor Marker) Mouse Monoclonal Antibody
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Catalog numberMBS439146
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PricePlease ask
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Size5x0.1 mg (With BSA & Azide at 0.2mg/mL)
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Products_typeAntibody
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Products_short_name[PlacentalAlkaline Phosphatase (PLAP)]
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Products_name_syn[Alkaline phosphatase placental type; Alkaline phosphatase Regan Isozyme; ALP; Alp1; ALPP; Germ-cell alkaline phosphatase; nagao Isozyme; PALP; Placental alkaline phosphatase 1; placental heat-stable alkaline phosphatase; PLAP-1; PLAP1]
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Other_names[alkaline phosphatase, placental type preproprotein; Alkaline phosphatase, placental type; alkaline phosphatase, placental type; alkaline phosphatase, placental; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1]
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Products_gene_name[ALPP]
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Other_gene_names[ALPP; ALPP; ALP; PALP; PLAP; PLAP-1; PLAP; PLAP-1]
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ClonalityMonoclonal
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Clone[SPM593]
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ReactivityHuman
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SpecificityReacts with a 70kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the gestational trophoblastic disease.
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Form200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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Storage_stabilityAntibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Tested_applicationFlow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
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PropertiesIf you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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DescriptionFor cells, cell lines and tissues in culture till half confluency.
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AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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French translationanticorps
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Gene target
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Gene symbolALPP, ASPN, LNPEP, PLAA
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Short namePlacentalAlkaline Phosphatase (PLAP) (Germ Tumor ) Mouse Monoclonal Antibody
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TechniqueMouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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HostMouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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IsotypeIgG2b, kappa
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SpeciesMouse, Mouses
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Alternative namePlacentalAlkaline Phosphatase (PLAP) (Germ cellular Tumor detection labelled) Mouse monoclonal (antibody to-)
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Alternative techniqueantibodies, murine
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Tissuecell, tumor
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Gene info
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Identity
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Gene
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Long gene namealkaline phosphatase, placental
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Synonyms gene name
- alkaline phosphatase, placental (Regan isozyme)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Alkaline phosphatases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameasporin
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Synonyms gene name
- asporin (LRR class 1)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-03-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small leucine rich repeat proteoglycans
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameleucyl and cystinyl aminopeptidase
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Synonyms gene name
- leucyl/cystinyl aminopeptidase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-07-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M1 metallopeptidases
- Aminopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namephospholipase A2 activating protein
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-04-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- WD repeat domain containing
- Armadillo like helical domain containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
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Tree numbers
- E01.370.225.500.383.910
- E01.370.225.500.388.930
- E05.200.500.383.910
- E05.200.500.388.930
- E05.242.383.910
- E05.242.417.500
- E05.337.550.200.800
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data