Mouse Monoclonal IgG1 Anti-MDM2 [SMP14]

Mouse Monoclonal IgG1 Anti-MDM2 [SMP14] is available 1 time from Bio logo labs

MDM001-0.5 | Mouse Monoclonal IgG1 Anti-MDM2 [SMP14]size: 0.5 ml | 522.85 USD

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  • Availability
    Please contact us to check the availability
  • Immunogen
    Synthetic peptide, corresponding to human MDM2 AS 154-167 (Cys-SRPSTSSRRRAISE)
  • Specificity
    Human MDM2, MW 90-95 kDa, Epitope 154-167, not reacting with Thr-216 phosphorylated MDR2 (Ref. 3)
  • Species reactivity
    Human, mouse, rat
  • Product presentation
    Protein G purified antibody in PBS pH 7.3 containing BSA and sodium azide* 0,09% as preservative
  • Product category
    Primary Antibody
  • Antibody's raised in
    Mouse
  • Antibody's isotype
    IgG1
  • Antibody's clone
    SMP14
  • Product is supplied as
    liquid concentrate
  • Recommended concentration for use
    1:50-1:100
  • Protein concentration
    N/A
  • Positive control
    Mamma carcinoma, Liposarcoma
  • Pretreatment
    Formalin-fixed tissue may be pre-treated for 30 min at 100°C with Unmasking Solution C (Citrate buffer pH 6, Art. No. DE000) or Unmasking Solution D (buffered EDTA/Citrate pH 8, Art. No. DE005)
  • Tested applications
    IHC(P)
  • Recommended secondary reagent
    Gentaur Universal Staining Kits Art.-No. DA005 (AE005) or VECTASTAIN Elite ABC Mouse IgG (Art.-No. PK-6102) or VECTOR ImmPRESS™ Mouse IgG Kit (Art. No. MP-7402)
  • Storage method
    Store at 2-8°C
  • UniProt number
    QGo to UniProt/SwissProtGo to UniProt/SwissProt987 (MDM2_HUMAN)
  • Litterature
    1. Picksley SM, Vojtesek B, Sparks A, Lane DP. Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides. Oncogene. 1994 Sep;9(9):2523-9. 2. Martin K, Trouche D, Hagemeier C, Sorensen TS, La Thangue NB, Kouzarides T. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature. 1995 Jun 22;375(6533):691-4. 3. Zhang T, Prives C.J Cyclin a-CDK phosphorylation regulates MDM2 protein interactions. Biol Chem. 2001 Aug 10;276(32):29702-10. 4. Tandon S, Beer H, Jones TM, Birchall M, Boyd M, Helliwell TR. Immunohistochemical expression of p53 and MDM2 within head and neck squamous cell carcinoma. Clin Otolaryngol. 2006 Jun;31(3):247. 5. Qi ZL, Huo X, Xu XJ, Zhang B, Du MG, Yang HW, Zheng LK, Li J, Shen ZY. Relationship between HPV16/18 E6 and 53, 21(WAF1), MDM2, Ki67 and cyclin D1 expression in esophageal squamous cell carcinoma: comparative study by using tissue microarray technology. Exp Oncol. 2006 Sep;28(3):235-40.
  • Tips
    *Gentaur's antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals. ** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • About
    Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
  • Test
    Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • Gene target
  • Short name
    Mouse Monoclonal IgG1 Anti-MDM2 [SMP14]
  • Technique
    Mouse monoclonal, Mouse, anti
  • Host
    mouse monoclonal
  • Isotype
    IgG1
  • Species
    Mouse
  • Alternative name
    Mouse monoclonal IgG1 antibody to-MDM2 [SMP14]
  • Alternative technique
    antibodies
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Mouse Monoclonal IgG1 Anti-MDM2 [SMP14] - Gentaur.com
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