Anti-TIF1 gamma Antibody (3H7-C8-B9)

• Catalog number
  A1313-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  TRIM33
• Target Alternative Name
  ECTO, PTC7, RFG7, TF1G, TIF1G, TIF gamma, TIF1gamma
• Antibody Type
  Monoclonal
• Clone
  3H7-C8-B9
• Species Reactivities
  Human
• Immunogen Sequence
  Recombinant human TIF1 gamma / TRIM33 protein fragments expressed in E.coli.
• Accession
  Q9UPN9
• Gene Id
  51592
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
• Purification
  Affinity purified
• Application
  WB
• Positive Control
  WB: MCF7 and HeLa nuclear extracts
• Application And Usages
  WB; 1:1000
• Description
  Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade)
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans
• Handling
  The antibody solution should be gently mixed before use
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TIF1   gamma   3H7-C8-B9  
• Gene symbol
  NDUFA3, B9D1, TRIM24
• Short name
  Anti-TIF1 gamma Antibody (3H7-C8-B9)
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Mouse IgG2a
• Alternative name
  Antibody toTIF1 g (antibody to-) (3H7-C8-B9)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7686
• Gene
  NDUFA3
• Long gene name
  NADH:ubiquinone oxidoreductase subunit A3
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 (9kD, B9)
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
• Synonyms
  • B9
• Synonyms name
  • complex I B9 subunit
• GenBank acession
  • AF044955
• Locus
  19q13.42
• Discovery year
  1996-08-30
• Entrez gene record
  4696
• Pubmed identfication
  • 9878551
• RefSeq identity
  • NM_004542
• Classification
  • NADH:ubiquinone oxidoreductase supernumerary subunits
• VEGA ID
  OTTHUMG00000064972

Gene info

• Identity
  HGNC:24123
• Gene
  B9D1
• Long gene name
  B9 domain containing 1
• Synonyms gene name
  • B9 protein domain 1
• Synonyms
  • B9
  • EPPB9
  • MKS9
  • MKSR-1
• Synonyms name
  • endothelial precursor protein B9
• GenBank acession
  • BC002944
• Locus
  17p11.2
• Discovery year
  2007-08-21
• Entrez gene record
  27077
• Pubmed identfication
  • 21493627
• RefSeq identity
  • NM_015681
• Classification
  • B9 domain containing
  • MKS complex
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000059586
• Locus Specific Databases
  • LRG_686

Gene info

• Identity
  HGNC:11812
• Gene
  TRIM24
• Long gene name
  tripartite motif containing 24
• Synonyms gene
  • TIF1
• Synonyms gene name
  • transcriptional intermediary factor 1
  • tripartite motif-containing 24
• Synonyms
  • hTIF1
  • Tif1a
  • RNF82
  • TIF1A
• GenBank acession
  • AF009353
• Locus
  7q33-q34
• Discovery year
  1998-12-18
• Entrez gene record
  8805
• Pubmed identfication
  • 9115274
  • 9191165
• RefSeq identity
  • NM_015905
• Classification
  • Ring finger proteins
  • Bromodomain containing
  • Tripartite motif containing
  • PHD finger proteins
• VEGA ID
  OTTHUMG00000155820

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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