Mouse Anti-Human Bax-UNLB
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Catalog number
MBS670007
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Price
Please ask
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Size
5x0.1 mg
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Products_type
Antibody
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Products_short_name
[Bax]
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Products_name_syn
[Mouse Anti-Human Bax - Purified, Unlabeled Antibody; Mouse Anti-Human Bax]
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Other_names
[bax; Apoptosis regulator BAX; apoptosis regulator BAX; Bcl2-associated X protein]
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Other_gene_names
[Bax; Bax; Bax]
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Clonality
Monoclonal
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Clone
[2D2]
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Reactivity
Human
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Specificity
Human Bax (Mr 21 kDa) Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems.2 It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment.3 Bax is a member of the Bcl-2 family of apoptosis-associated proteins and, although it is similar in structure to Bcl-2, Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial membranes, inducing mitochondrial damage and subsequent cell death in a caspase-independent manner, presumably via their ion channel-forming activity. These channels may then function to promote a mitochondrial permeability transition or to puncture the outer mitochondrial membrane. In addition to forming homodimer, Bax can heterodimerize with Bcl-2 and Bcl-XL proteins. This heterodimerization between pro- and anti-apoptotic family members may serve a titration function and act as a sensor for the programmed cell death program.4-13 Mab 2D2 is specific for human Bax.1
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Form
Purified (UNLB) Antibody
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Storage_stability
The purified (UNLB) antibody is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added. Store at 2-8 degree C. The products should be stored at 2-8 degree C. Each product is stable for the period shown on the label if stored as directed.
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Tested_application
ELISA; Immunohistochemistry (Acetone Fixed/Frozen Sections); Immunoprecipitation; Western Blot
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Test
MyBioSource supplies antibodies that are for research of human proteins. Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Latin name
Mus musculus
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Gene target
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Short name
Mouse Anti- Bax-UNLB
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Technique
anti-Human, anti-, Mouse, anti, antibody to, antibodies, antibodies against human proteins, mouses
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Host
Mouse
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Isotype
Mouse IgG1
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Species
Human, Humans, Mouses
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Alternative name
Mouse Antibody toHuman BCL2-associated X protein-UNLB
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Alternative technique
murine, antibodies
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Alternative to gene target
BCL2-associated X protein, BCL2L4, BAX and IDBG-61459 and ENSG00000087088 and 581, BH3 domain binding, nuclei, Bax and IDBG-183241 and ENSMUSG00000003873 and 12028, BAX and IDBG-640344 and ENSBTAG00000013340 and 100850136,280730
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MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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