MOUSE Anti-SOS1 Antibody

• Catalog number
  GEN217406
• Price
  Please ask
• Size
  100ug

• Also known as
  SOS1
• Other names
  son of sevenless homolog 1; Son of sevenless homolog 1; son of sevenless homolog 1; SOS-1; guanine nucleotide exchange factor; gingival fibromatosis, hereditary, 1; son of sevenless homolog 1 (Drosophila); N/A
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  SOS1
• Gene name synonims
  N/A
• Other gene names
  SOS1; SOS1; GF1; HGF; NS4; GGF1; GINGF; SOS-1
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG1
• Clone
  SOS-1
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  SOS1 This item specifically recognises SOS1 (son of sevenless homolog 1), a ubiquitously expressed 150kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. _x000D__x000D_Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  Purified (Purified IgG - liquid)
• Concentration
  IgG concentration 1.0mg/ml
• Storage and shipping
  Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term.Storage in frost-free freezers is not recommended. the antibody should be stored undiluted. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 18 months from date of dispatch.
• Tested applications
  Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  SOS1  
• Gene symbol
  SOS1-IT1, SOS1
• Short name
  MOUSE Anti-SOS1 Antibody
• Technique
  Antibody, anti-, Mouse, anti, antibody to, antibodies, antibodies against human proteins, antibodies for, mouses
• Host
  mouse
• Species
  Mouse, Mouses
• Alternative name
  Anti-MOUSE ANTI SOS1
• Alternative technique
  antibodies, murine
• Alternative to gene target
  son of sevenless homolog 1 (Drosophila), GF1 and GGF1 and GINGF and HGF and NS4, SOS1 and IDBG-47279 and ENSG00000115904 and 6654, protein heterodimerization activity, Plasma membranes, Sos1 and IDBG-199949 and ENSMUSG00000024241 and 20662, SOS1 and IDBG-632726 and ENSBTAG00000011643 and 537682

Gene info

• Identity
  HGNC:41385
• Gene
  SOS1-IT1
• Long gene name
  SOS1 intronic transcript 1
• Synonyms gene name
  • SOS1 intronic transcript 1 (non-protein coding)
• Locus
  2p22.1
• Discovery year
  2011-05-20
• Entrez gene record
  100505911
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000153569

Gene info

• Identity
  HGNC:11187
• Gene
  SOS1
• Long gene name
  SOS Ras/Rac guanine nucleotide exchange factor 1
• Synonyms gene
  • GINGF
• Synonyms gene name
  • gingival fibromatosis, hereditary, 1
  • son of sevenless homolog 1 (Drosophila)
• Synonyms
  • HGF
  • GF1
• GenBank acession
  • L13857
• Locus
  2p22.1
• Discovery year
  1993-10-27
• Entrez gene record
  6654
• Pubmed identfication
  • 8276400
  • 10995566
• RefSeq identity
  • NM_005633
• Classification
  • Dbl family Rho GEFs
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000102109
• Locus Specific Databases
  • LRG_754

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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