MMP 24 (MT5-MMP) catalytic domain, His-tagged (Recombinant Protein)
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Catalog number30 100 903
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PricePlease ask
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Size200 µg/ 1 ml
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Protein typeRecombinant
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Protein subtypeEC 3.4.24.80
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Protein familyMatrix Metalloproteinases, matrixins
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Protein descriptionMMP24 is a metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
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Research area interestsAmong MMP24 related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix.
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Package formliquid
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Tested applicationsActivation of progelatinase A; Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
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Other namesMembrane-Type 5 Matrix Metalloproteinase
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Peptide sequenceY A L T G Q K W R Q K H I T Y S I H N Y T P K V G E L D T R K A I R Q A F D V W Q K V T P L T F E E V P Y H E I K S D R K E A D I M I F F A S G F H G D S S P F D G E G G F L A H A Y F P G P G I G G D T H F D S D E P W T L G N A N H D G N D L F L V A V H E L G H A L G L E H S S D P S A I M A P F Y Q Y M E T H N F K L P Q D D L Q G I Q K I Y G P P A E P L E P T R P L P T L P V R R I H S P S V T H H H H H H
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Available target modificationNo
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Expression systemE.coli
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Product Subtypeprotein fragment
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Active formYes
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TagHis-tagged
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Contents50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2.
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Protein purity> 90 %
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Molecular weight22 kDa
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UniProt numberQ9Y5R2
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Gene number10893
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AbbreviationMMP24 (partial)
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Full namematrix metallopeptidase 24 (partial)
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Other desciptionThe catalytic domain of human MT5-MMP is produced by activation of a recombinant soluble proform of MT5-MMP purified from E. coli periplasm.
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PurificationMentioned in the data sheet
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PubMed citationsSee the data sheet
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WarningsFor Research Use only.
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Shipping conditionsdry ice
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Storage conditionStore at -70°C
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Technical datasheetContact us to receive the datasheet
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Conjugationhistidine
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolMMP24, MMP14, MMP28, MMP17, MMP15, MMP25, MMP16
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Short nameMMP 24 (MT5-MMP) catalytic domain, His-tagged (Recombinant Protein)
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Labelhis-tagged
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SpeciesHomo sapiens
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Alternative nameMMP 24 (MT5-MMP) catalytic domain, histidine-tagged (Rec. Protein)
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 24
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Synonyms gene name
- matrix metalloproteinase 24 (membrane-inserted)
- matrix metallopeptidase 24 (membrane-inserted)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-08-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 14
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Synonyms gene name
- matrix metalloproteinase 14 (membrane-inserted)
- matrix metallopeptidase 14 (membrane-inserted)
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Synonyms
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Synonyms name
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Locus
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Discovery year1994-11-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 28
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Synonyms gene name
- matrix metalloproteinase 28
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-01-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 17
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Synonyms gene name
- matrix metalloproteinase 17 (membrane-inserted)
- matrix metallopeptidase 17 (membrane-inserted)
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-11-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 15
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Synonyms gene name
- matrix metalloproteinase 15 (membrane-inserted)
- matrix metallopeptidase 15 (membrane-inserted)
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-11-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 25
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Synonyms gene
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Synonyms gene name
- matrix metalloproteinase 25
- matrix metallopeptidase-like 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-12-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 16
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Synonyms gene
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Synonyms gene name
- matrix metalloproteinase 16 (membrane-inserted)
- chromosome 8 open reading frame 57
- matrix metallopeptidase 16 (membrane-inserted)
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-11-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data