MLN-8054

Alternative_name

4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid
Description

MLN-8054 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ = 4 nM). Displays 40-fold selectivity for Aurora A over Aurora B.
CAS Number

869363-13-3
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₅H₁₅ClF₂N₄O₂
Molecular Weight

476.86
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>35 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective Aurora kinase A inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

11712649
PubChem CID Link
SMILES

C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O
InChi

InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32)
InChi Key

HHFBDROWDBDFBR-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes