Mitochondrial Permeability Transition Pore Assay Kit

• Catalog number
  K239-100
• Price
  Please ask
• Size
  100 assays

• Description
  Distinguishes between apoptotic & healthy cells
• Summary
  • Detection method- Flow cytometry (Ex 488 nm) • Species reactivity- Mammalian • Applications- • Measure mitochondrial permeability transition pore activity in cells • Assessment of physiological mediators and antibodies that affect cell viability/cytotoxicity
• Detection Method
  Flow cytometry (Ex 488 nm)
• Species Reactivity
  Mammalian
• Applications
  • Measure mitochondrial permeability transition pore activity in cells • Assessment of physiological mediators and antibodies that affect cell viability/cytotoxicity
• Sample Type
  Cells (adherent and suspension)
• Features Benefits
  • Simple procedure • Fast, convenient and sensitive • The assay provides a direct method of measuring mitochondrial permeability transition pore activation as an early marker of apoptosis
• Storage Conditions
  -20°C
• Shipping Conditions
  gel pack
• Shelf life
  12 months
• Background
  Mitochondria are the power centrals of the cell and play an essential role in energy production. Damage to mitochondria activates signaling pathways that induce apoptosis. The mitochondrial permeability transition pore (MPT pore or MPTP) is a nonspecific channel formed by components of the inner and outer mitochondrial membranes, and appears to be involved in the release of mitochondrial components during cell death. In healthy cells, MPTP’s flicker between open and closed states but during cell death MPTP’s dramatically alter the permeability of the mitochondria. Cytochrome c release and loss of mitochondrial membrane potential are subsequent to continuous pore activation. BioVision’s Mitochondrial Permeability Transition Pore Assay Kit provides a direct method of measuring cell death by measuring MPTP opening rather than relying on mitochondrial membrane potential alone.
• Data Sheet Link
• Test
  Biovision supplies other types of Assays as 1.

• Gene target
  Mitochondrial   Permeability   Transition   Pore   Kit  
• Short name
  Mitochondrial Permeability Transition Pore Assay Kit
• Technique
  Assay, assays
• Host
  Assay
• Alternative name
  Mitochondrial Permeability Transition Pore test reagent
• Alternative technique
  arrays, kits
• Alternative to gene target
  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832
• Tissue
  mitochondrial

MeSH Data

• Name
  Radioimmunosorbent Test
• Concept
  Scope note: Radioimmunoassay of proteins using antibody coupled to an immunosorbent.
• Tree numbers
  • E05.478.566.380.830
  • E05.478.566.639.830
  • E05.601.470.380.830
  • E05.601.470.639.830
• Qualifiers
  ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data

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