MIF-Antagonist, ISO-1

Alternative_name

(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester
Description

Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS- treated wild type mice but has no effect on cytokine release from MIF deficient macrophages.
CAS Number

478336-92-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₂H₁₃NO₄
Molecular Weight

235.24
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~25 mg/ml)
Handling

Protect from air and light
Tag Line

A migration inhibitory factor (MIF) antagonist
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD22376813
PubChem CID

6098948
PubChem CID Link
SMILES

COC(=O)CC1CC(=C2C=CC(=O)C=C2)NO1
InChi

InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,13H,6-7H2,1H3
InChi Key

CLVQGFPQFNASJH-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes
Additional description

The antagonist receptor ligand binding will be in contrast with agonist activity. Biovision produces more antagonist and receptor related products as 1.

Gene target

MIF-Antagonist ISO-1
Gene symbol

MIF-AS1, MIF, ODC1-DT, DDT, EIF1, SS18L2, SRR, S100A9, OLFML3, TBX3
Short name

MIF-Antagonist, ISO-1
Alternative name

macrophage migration inhibitory factor (glycosylation-inhibiting factor)-Antagonist, ISO-1
Alternative to gene target

macrophage migration inhibitory factor (glycosylation-inhibiting factor), GIF and GLIF and MMIF, MIF and IDBG-401910 and ENSG00000240972 and 4282, phenylpyruvate tautomerase activity, Extracellular, Mif and IDBG-163956 and ENSMUSG00000033307 and 17319, MIF and IDBG-637094 and ENSBTAG00000007375 and 280858

Identity

HGNC:7097
Gene

MIF
Long gene name

macrophage migration inhibitory factor
Synonyms gene
- GLIF
Synonyms gene name
- macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Synonyms
- GIF
Synonyms name
- glycosylation-inhibiting factor
- phenylpyruvate tautomerase
GenBank acession
- M25639
Locus

22q11.23
Discovery year

1993-10-15
Entrez gene record

4282
Pubmed identfication
- 7558020
- 2552447
RefSeq identity
- NM_002415
VEGA ID

OTTHUMG00000150773

Identity

HGNC:15593
Gene

SS18L2
Long gene name

SS18 like 2
Synonyms gene name
- synovial sarcoma translocation gene on chromosome 18-like 2
Synonyms
- KIAA-iso
Synonyms name
- SYT homolog 2
GenBank acession
- AF201950
Locus

3p22.1
Discovery year

2001-04-26
Entrez gene record

51188
Pubmed identfication
- 11435705
RefSeq identity
- NM_016305
VEGA ID

OTTHUMG00000131794

Identity

HGNC:10499
Gene

S100A9
Long gene name

S100 calcium binding protein A9
Synonyms gene
- CAGB
- CFAG
Synonyms gene name
- calgranulin B
- S100 calcium-binding protein A9 (calgranulin B)
Synonyms
- P14
- MIF
- NIF
- LIAG
- MRP14
- MAC387
- 60B8AG
- CGLB
- MRP-14
- S100-A9
Synonyms name
GenBank acession
- BC047681
Locus

1q21.3
Discovery year

1989-05-19
Entrez gene record

6280
RefSeq identity
- NM_002965
Classification
- S100 calcium binding proteins
- EF-hand domain containing
VEGA ID

OTTHUMG00000013125