Mib1 Antibody (Mindbomb)

• Catalog number
  F47999-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Mib1 (Mindbomb)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  IF, IHC, WB, ELISA
• Recommended dilutions
  Western blot: 1:1000,Immunofluorescence: 1:20-1:100,IHC (Paraffin): 1:50-1:100
• Notes
  Titration of the Mib1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Mib1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q86YT6
• Purity
  Purified
• Description
  MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
• Immunogen
  A portion of amino acids 13-42 from the human protein was used as the immunogen for this Mib1 antibody.
• Storage
  Aliquot the Mib1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Mib1   Mindbomb  
• Gene symbol
  MIB1
• Short name
  Anti-Mib1 (Mindbomb)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to Mib1 (Mindbomb)
• Alternative technique
  antibodies
• Alternative to gene target
  mindbomb E3 ubiquitin protein ligase 1, MIB1 and IDBG-1441 and ENSG00000101752 and 57534, metal ion binding, Plasma membranes, Mib1 and IDBG-128545 and ENSMUSG00000024294 and 225164, MIB1 and IDBG-644034 and ENSBTAG00000007467 and 533735

Gene info

• Identity
  HGNC:21086
• Gene
  MIB1
• Long gene name
  MIB E3 ubiquitin protein ligase 1
• Synonyms gene name
  • mindbomb homolog 1 (Drosophila)
• Synonyms
  • DIP-1
  • MIB
  • KIAA1323
  • ZZANK2
  • ZZZ6
• Synonyms name
  • DAPK-interacting protein 1
• GenBank acession
  • AB037744
• Locus
  18q11.2
• Discovery year
  2004-06-18
• Entrez gene record
  57534
• RefSeq identity
  • NM_020774
• Classification
  • Ankyrin repeat domain containing
  • MicroRNA protein coding host genes
  • Ring finger proteins
  • Zinc fingers ZZ-type
• VEGA ID
  OTTHUMG00000131753
• Locus Specific Databases
  • LRG_759

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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