Meis homeobox 3 Antibody

• Catalog number
  bs-11889R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Meis homeobox 3 Primary Polyclonal Antibody
• Also known as
  Meis homeobox 3 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Meis homeobox 3
• Specificity
  This is a highly specific antibody against Meis homeobox 3.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Meis homeobox 3
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Hox, Pbx and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Hox proteins are involved in regulating tissue patterning during development, and are also expressed in lineage- and stage-specific patterns during adult hematopoietic differentiation and in leukemias. The Hox proteins, which include paralog groups 1-10, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx- related Meis proteins, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site. Both Meis1 and Meis2 (also known as Meis-related gene 1 or Mrg1) are members of the TALE (“three amino acid loop extensionâ€) family of homeodomain-containing proteins. In addition to binding with Hox proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, including Pbx1, Pbx2 and Pbx3, and these complexes contain distinct DNA-binding specificities. Like Hox and Pbx proteins, Meis1 is implicated in oncogenesis, as it is overexpressed as a result of adjacent retroviral insertion in BHX-2 myeloid leukemias. Two Meis-related proteins, Meis2 and Meis3 (also designated Mrg1 and Mrg2, respectively), possess largely similar sequence identity with Meis1 and are expressed in normal tissues and myeloid leukemias. In the pancreas, Meis2 preferentially associates with Pbx1, and together they associate with the pancreas-specific homeodomain factor, Pdx1, to repress Pdx1-induced transcriptional activation.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Homeobox protein meis3; Meis1 myeloid ecotropic viral integration site 1 homolog 3; Meis1 related protein 2; Meis1-related protein 2 antibodymeis3; MEIS3_HUMAN; MRG2.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Meis   homeobox  
• Gene symbol
  MEIS3P2, MEIS3, MEIS3P1
• Short name
  Anti-Meis homeobox 3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Meis homeobox 3 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:17638
• Gene
  MEIS3P2
• Long gene name
  Meis homeobox 3 pseudogene 2
• Synonyms gene name
  • Meis1 homolog 3 (mouse) pseudogene 2
• Locus
  17p11.2
• Discovery year
  2005-12-23
• Entrez gene record
  257468
• RefSeq identity
  • NG_002418
• Classification
  • TALE class homeoboxes and pseudogenes
• VEGA ID
  OTTHUMG00000059559

Gene info

• Identity
  HGNC:29537
• Gene
  MEIS3
• Long gene name
  Meis homeobox 3
• Synonyms gene name
  • Meis1, myeloid ecotropic viral integration site 1 homolog 3 (mouse)
• Synonyms
  • MRG2
  • DKFZp547H236
• GenBank acession
  • BC025404
• Locus
  19q13.32
• Discovery year
  2004-02-10
• Entrez gene record
  56917
• Pubmed identfication
  • 8950991
• RefSeq identity
  • NM_020160
• Classification
  • TALE class homeoboxes and pseudogenes
• VEGA ID
  OTTHUMG00000172280

Gene info

• Identity
  HGNC:7002
• Gene
  MEIS3P1
• Long gene name
  Meis homeobox 3 pseudogene 1
• Synonyms gene
  • MEIS3
  • MEIS4
• Synonyms gene name
  • Meis1, myeloid ecotropic viral integration site 1 homolog 3 (mouse)
  • Meis1, myeloid ecotropic viral integration site 1 homolog 4 (mouse)
  • Meis1 homolog 3 (mouse) pseudogene 1
• Synonyms
  • MRG2
• GenBank acession
  • U68385
• Locus
  17p12
• Discovery year
  1998-02-09
• Entrez gene record
  4213
• Pubmed identfication
  • 9049632
• Classification
  • TALE class homeoboxes and pseudogenes
• VEGA ID
  OTTHUMG00000059145

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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