MCAK Antibody

• Catalog number
  R31643
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  MCAK
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the MCAK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This MCAK antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  11004
• Purity
  Antigen affinity
• Description
  Kinesin-like protein, also called Mitotic centromere associated kinesin (MCAK), is a protein that in humans is encoded by the KIF2C gene. It is mapped to 1p34.1. The protein encoded by this gene is a member of kinesin-like protein family. Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation. MCAK uses microtubule depolymerizing activity to correct improper microtubule attachments at kinetochores.
• Immunogen
  Human partial recombinant protein (AA 531-725) was used as the immunogen for this MCAK antibody.
• Storage
  After reconstitution, the MCAK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MCAK  
• Gene symbol
  KIF2C
• Short name
  Anti-MCAK
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to MCAK
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6393
• Gene
  KIF2C
• Long gene name
  kinesin family member 2C
• Synonyms gene
  • KNSL6
• Synonyms gene name
  • kinesin-like 6 (mitotic centromere-associated kinesin)
• Synonyms
  • MCAK
  • CT139
• GenBank acession
  • U63743
• Locus
  1p34.1
• Discovery year
  1999-09-07
• Entrez gene record
  11004
• Pubmed identfication
  • 9434124
• RefSeq identity
  • NM_006845
• Classification
  • Kinesins
  • Small nucleolar RNA protein coding host genes
• VEGA ID
  OTTHUMG00000008416

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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