BAP1 (Ser592) Antibody, ALEXA FLUOR 555

• Catalog number
  bs-3051R-A555
• Price
  Please ask
• Size
  100ul

• Long name
  BAP1 (Ser592) Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
• Also known as
  Anti-BAP1 Ser592 PAb ALEXA FLUOR 555
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 555
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  BAP1 Ser592
• Specificity
  This is a highly specific antibody against BAP1 Ser592.
• Modification
  Phosphorylation
• Modification Site
  Ser592
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  570-620/729
• Subcellular location
  Cytoplasm, Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human BAP1 around the phosphorylation site of Ser592
• Gene ID Number
  8314
• Swiss Prot
  Q92560
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  553nm/568nm
• Synonyms
  UCHL2; hucep-6; HUCEP-13; Ubiquitin carboxyl-terminal hydrolase BAP1; BRCA1-associated protein 1; Cerebral protein 6; BAP1; KIAA0272
• Properties
  For facs or microscopy Alexa 1 conjugate. Very high photo stable ALEXA conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 555
• French translation
  anticorps

• Gene target
  BAP1   Ser592  
• Gene symbol
  BAP1, MAGI1, RNF2
• Short name
  Anti-BAP1 Ser592
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 555
• Alternative name
  BAP1 (Ser592) Polyclonal Antibody, ALEXA FLUOR 555
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:950
• Gene
  BAP1
• Long gene name
  BRCA1 associated protein 1
• Synonyms gene name
  • BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
• Synonyms
  • hucep-6
  • KIAA0272
  • UCHL2
• Synonyms name
  • ubiquitin carboxy-terminal hydrolase
• GenBank acession
  • AF045581
• Locus
  3p21.1
• Discovery year
  1998-09-17
• Entrez gene record
  8314
• Pubmed identfication
  • 9528852
• Classification
  • Ubiquitin C-terminal hydrolases
• VEGA ID
  OTTHUMG00000158392
• Locus Specific Databases
  • LRG_529

Gene info

• Identity
  HGNC:946
• Gene
  MAGI1
• Long gene name
  membrane associated guanylate kinase, WW and PDZ domain containing 1
• Synonyms gene
  • BAIAP1
• Synonyms gene name
  • BAI1-associated protein 1
• Synonyms
  • BAP1
  • MAGI-1
  • TNRC19
  • AIP3
  • WWP3
• GenBank acession
  • AB010894
• Locus
  3p14.1
• Discovery year
  1998-09-29
• Entrez gene record
  9223
• Pubmed identfication
  • 9647739
  • 9225980
• RefSeq identity
  • NM_004742
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000157554

Gene info

• Identity
  HGNC:10061
• Gene
  RNF2
• Long gene name
  ring finger protein 2
• Synonyms
  • BAP-1
  • BAP1
  • DING
  • HIPI3
  • RING1B
  • RING2
• GenBank acession
  • BC012583
  • Y10571
• Locus
  1q25.3
• Discovery year
  1997-06-09
• Entrez gene record
  6045
• Pubmed identfication
  • 11513855
• RefSeq identity
  • NM_007212
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000035391

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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