mAb Anti Human PD-L1 clone 12B4, Tracer (Biotin) (Monoclonal)

• Catalog number
  MBS590085
• Price
  Please ask
• Size
  5x0.1 mL

• Products_type
  Antibody
• Products_short_name
  [PD-L1]
• Products_name_syn
  [mAb anti-Human PD-L1; Mouse monoclonal antibody (mAb) to human programmed death-ligand 1 (PD-L1); mouse mAb to B7H1; mouse mAb to human CD274, Tracer (Biotin Labeled); Biotin conjugated Mouse monoclonal antibody (mAb) to human programmed death-ligand 1 (PD-L1)]
• Other_names
  [programmed cell death 1 ligand 1 isoform c; Programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; CD274 molecule; B7 homolog 11 PublicationManual assertion based on opinion iniRef.1"B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion."Dong H., Zhu G., Tamada K., Chen L.Nat. Med. 5:1365-1369(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INDUCTION.]
• Products_gene_name
  [PD-L1]
• Other_gene_names
  [CD274; CD274; B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1; PD-L12 PublicationsManual assertion based on opinion iniRef.10; PDCD1 ligand 1; Programmed death ligand 1; B7-H11 PublicationManual assertion based on opinion iniRef.1]
• Clonality
  Monoclonal
• Clone
  [12B4]
• Reactivity
  Human. Others not tested.
• Specificity
  Reactive with human programmed death-ligand 1 (PD-L1).
• Purity
  Protein G Affinity Purified
• Form
  Lyophilized from a solution in 0.01M PBS, pH 7.2
• Storage_stability
  Store at -20 degree C. Avoid repeated freeze/thaw cycles after reconstitution.
• Tested_application
  ELISA (EIA)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
• Properties
  Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Conjugation
  Biotinylated
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.

• Gene target
  mAb   PD-L1   12B4   Tracer   Monoclonal  
• Gene symbol
  CD274, ENPP2, MTA2, MICALL1, IGKV1-16, ZBTB4, UCHL1, COLEC10, PDCD1, FAM71F1
• Short name
  mAb Anti PD-L1 clone 12B4, Tracer ( ) (Monoclonal)
• Technique
  anti human, anti, antibody to, anti human antibodies, Monoclonals or monoclonal antibodies
• Host
  Mouse
• Isotype
  IgG1,k
• Label
  Biotin
• Species
  Human, Humans
• Alternative name
  monoclonal antibody to H. sapiens PD-L1 clonality 12B4, Tracer (biotinilated) (monoclonal)
• Alternative technique
  antibodies
• Clone name
  12B4

Gene info

• Identity
  HGNC:17635
• Gene
  CD274
• Long gene name
  CD274 molecule
• Synonyms gene
  • PDCD1LG1
• Synonyms gene name
  • programmed cell death 1 ligand 1
  • CD274 antigen
• Synonyms
  • B7-H
  • B7H1
  • PD-L1
  • PDL1
  • B7-H1
• Synonyms name
  • B7 homolog 1
• GenBank acession
  • AF177937
• Locus
  9p24.1
• Discovery year
  2003-11-13
• Entrez gene record
  29126
• Pubmed identfication
  • 11015443
  • 10581077
• RefSeq identity
  • NM_014143
• Classification
  • Receptor ligands
  • C2-set domain containing
  • V-set domain containing
  • B7 family
  • CD molecules
• VEGA ID
  OTTHUMG00000019503

Gene info

• Identity
  HGNC:3357
• Gene
  ENPP2
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 2
• Synonyms gene
  • PDNP2
• Synonyms
  • ATX
  • PD-IALPHA
• Synonyms name
  • autotaxin
• GenBank acession
  • D45421
• Locus
  8q24.12
• Discovery year
  1995-08-10
• Entrez gene record
  5168
• Pubmed identfication
  • 8586446
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
• VEGA ID
  OTTHUMG00000164995

Gene info

• Identity
  HGNC:7411
• Gene
  MTA2
• Long gene name
  metastasis associated 1 family member 2
• Synonyms gene
  • MTA1L1
• Synonyms gene name
  • metastasis associated gene family, member 2
• Synonyms
  • MTA1-L1
• GenBank acession
  • AB016591
• Locus
  11q12.3
• Discovery year
  1999-05-17
• Entrez gene record
  9219
• Pubmed identfication
  • 9929979
• RefSeq identity
  • NM_004739
• Classification
  • GATA zinc finger domain containing
  • NuRD complex subunits
  • Myb/SANT domain containing
• VEGA ID
  OTTHUMG00000167684

Gene info

• Identity
  HGNC:29804
• Gene
  MICALL1
• Long gene name
  MICAL like 1
• Synonyms gene name
  • MICAL-like 1
• Synonyms
  • MIRAB13
  • KIAA1668
  • MICAL-L1
• Synonyms name
  • molecule interacting with Rab13
• GenBank acession
  • BK000466
• Locus
  22q13.1
• Discovery year
  2006-11-24
• Entrez gene record
  85377
• Pubmed identfication
  • 11258795
  • 12110185
• RefSeq identity
  • NM_033386
• Classification
  • LIM domain containing
• VEGA ID
  OTTHUMG00000150670

Gene info

• Identity
  HGNC:5732
• Gene
  IGKV1-16
• Long gene name
  immunoglobulin kappa variable 1-16
• Synonyms
  • IGKV116
  • L1
• GenBank acession
  • J00248
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28938
• RefSeq identity
  • NG_000834
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151649

Gene info

• Identity
  HGNC:23847
• Gene
  ZBTB4
• Long gene name
  zinc finger and BTB domain containing 4
• Synonyms
  • KIAA1538
  • KAISO-L1
  • ZNF903
• GenBank acession
  • AB040971
• Locus
  17p13.1
• Discovery year
  2003-12-15
• Entrez gene record
  57659
• Pubmed identfication
  • 16354688
  • 25499219
• RefSeq identity
  • NM_020899
• Classification
  • BTB domain containing
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000108137

Gene info

• Identity
  HGNC:12513
• Gene
  UCHL1
• Long gene name
  ubiquitin C-terminal hydrolase L1
• Synonyms gene
  • PARK5
• Synonyms gene name
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
• Synonyms
  • PGP9.5
  • Uch-L1
• Synonyms name
  • ubiquitin thiolesterase
• GenBank acession
  • BC000332
• Locus
  4p13
• Discovery year
  1991-07-15
• Entrez gene record
  7345
• Pubmed identfication
  • 1840236
• RefSeq identity
  • NM_004181
• Classification
  • Ubiquitin C-terminal hydrolases
• VEGA ID
  OTTHUMG00000099377

Gene info

• Identity
  HGNC:2220
• Gene
  COLEC10
• Long gene name
  collectin subfamily member 10
• Synonyms gene name
  • collectin sub-family member 10 (C-type lectin)
• Synonyms
  • CL-L1
  • CL-10
• GenBank acession
  • AB002631
• Locus
  8q24.12
• Discovery year
  2000-04-11
• Entrez gene record
  10584
• Pubmed identfication
  • 10224141
• Classification
  • Collectins
  • C-type lectin domain containing
  • Complement system activation components
• VEGA ID
  OTTHUMG00000164971

Gene info

• Identity
  HGNC:8760
• Gene
  PDCD1
• Long gene name
  programmed cell death 1
• Synonyms gene
  • SLEB2
• Synonyms gene name
  • systemic lupus erythematosus susceptibility 2
• Synonyms
  • CD279
  • PD1
  • hSLE1
  • PD-1
• GenBank acession
  • AY206416
• Locus
  2q37.3
• Discovery year
  1994-05-24
• Entrez gene record
  5133
• Pubmed identfication
  • 7851902
  • 12402038
• RefSeq identity
  • NM_005018
• Classification
  • V-set domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000151342

Gene info

• Identity
  HGNC:30704
• Gene
  FAM71F1
• Long gene name
  family with sequence similarity 71 member F1
• Synonyms gene
  • FAM137A
• Synonyms gene name
  • family with sequence similarity 137, member A
  • family with sequence similarity 71, member F1
• Synonyms
  • NYD-SP18
  • GARI-L1
• Synonyms name
  • Golgi-associated RAB2B interactor like 1
• GenBank acession
  • AF367470
• Locus
  7q32.1
• Discovery year
  2007-07-24
• Entrez gene record
  84691
• Pubmed identfication
  • 12477932
  • 34714330
• RefSeq identity
  • NM_032599
• VEGA ID
  OTTHUMG00000158276

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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