LY364947 for cell activation

LY364947 for cell activation is available 2 times from Biovision labs

2646-1 | LY364947 for cell activationsize: 1 mg | 155.22 USD

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2646-5 | LY364947 for cell activationsize: 5 mg | 423.32 USD

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  • Description
    LY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC₅₀ value of 59 nM. LY364947 only weakly inhibits TGF-β RII (IC₅₀ = 400 nM), p38 MAPK (IC₅₀ = 740 nM), and mixed lineage kinase-7 (MLK-7; IC₅₀ = 1,400 nM).It inhibits TGF-β-induced cell growth (IC₅₀ = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-β-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.
  • Peptide sequence
    N/A
  • CAS number
    396129-53-6
  • Molecular weight
    272.31
  • Category
    Biochemicals
  • Other name
    4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline; HTS 466284
  • Molecular formula
    C₁₇H₁₂N₄
  • Physical appearance
    Off-white solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥98% by HPLC
  • Reconstitute instructions
    DMSO (~ 25 mg/ml)
  • Storage condition
    -20°C
  • Shipping condition
    gel pack
  • Maximum time for storage
    48 months
  • Storage instructions
    Protect from air and light
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    LY364947 for activation
  • Technique
    activation
  • Alternative name
    LY364947 to measure cellular activation
  • Tissue
    cell
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