LY364947,ALK5 kinase inhibitor
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Catalog numberSIH-504-25MG
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PricePlease ask
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Size25 mg
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Research Area sCell Signaling , Cancer , Apoptosis , Cancer Growth Inhibitors , Tyrosine Kinase Inhibitors
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CategorySmall Molecules
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Product TypeInhibitor
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CAS No396129-53-6
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MolecularFormulaC17H12N4
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Molecular Weight272.3
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Purity≥98% (HPLC)
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SolubilitySoluble to 100 mM in DMSO
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AppearanceYellow to brown solid
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Storage Temperature-20°C
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Shipping TemperatureShipped Ambient
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DescriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolTGFBR1
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Short nameLY364947 ALK5 kinase inhibitor
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Alternative nameLY364947,ALK5 phosphorylation catalyst suppressor
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Gene info
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Identity
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Gene
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Long gene nametransforming growth factor beta receptor 1
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Synonyms gene
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Synonyms gene name
- multiple self-healing squamous epithelioma
- transforming growth factor beta receptor I
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Synonyms
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Synonyms name
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Locus
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Discovery year1993-09-30
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Entrez gene record
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Pubmed identfication
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Classification
- Type 1 receptor serine/threonine kinases
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VEGA ID
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Locus Specific Databases