LSD1, NT (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC Complex Protein BHC110, Flavin-containing Amine Oxidase Domain-containing Protein 2, KDM1A, AOF2, KDM1, KIAA0601)

  • Catalog number
    MBS644623
  • Price
    Please ask
  • Size
    0.05 mg
  • Products_type
    Antibody
  • Products_short_name
    [LSD1]
  • Products_name_syn
    [Anti -LSD1, NT (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC Complex Protein BHC110, Flavin-containing Amine Oxidase Domain-containing Protein 2, KDM1A, AOF2, KDM1, KIAA0601)]
  • Other_names
    [lysine-specific histone demethylase 1A; lysine-specific histone demethylase 1A; lsd1; lysine (K)-specific demethylase 1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethylase 1a]
  • Other_gene_names
    [kdm1a; aof2; kdm1; wu:fb82e06; wu:fc51a02; wu:fj36a05; wu:fj66b06]
  • Clonality
    Polyclonal
  • Reactivity
    Human
  • Specificity
    Recognizes human KDM1A. Species sequence homology: Mouse, rat.
  • Purity
    Affinity Purified Purified by immunoaffinity chromatography.
  • Form
    Supplied as a liquid in PBS, 0.02% sodium azide.
  • Storage_stability
    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
  • Tested_application
    Western Blot (WB), Immunohistochemistry (IHC)
  • Gene
    Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the Flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.
  • Gene target
    LSD1   Lysine-specific   Histone   Demethylase   BRAF35-HDAC   Complex   Protein   BHC110   Flavin   Amine   Oxidase   Domain   Protein   KDM1A   AOF2   KDM1   KIAA0601  
  • Gene symbol
    KDM1A, HDAC4, HDAC9, HMG20B
  • Short name
    LSD1, NT (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC Complex Protein BHC110, Flavin- Amine Oxidase Domain- Protein 2, KDM1A, AOF2, KDM1, KIAA0601)
  • Host
    Rabbit
  • Alternative name
    LSD1, NT (Lysine-specific Histone Demethylase 1A, BRAF35-HDAC aggregate Protein BHC110, Flavin-containing Amine Oxidase Domain-containing Protein 2, KDM1A, AOF2, KDM1, KIAA0601)
Gene info
Gene info
Gene info
Gene info
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Filters
LSD1 NT Lysine specific Histone Demethylase 1A BRAF35 HDAC C
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