LRP6 (Ser1490) Antibody

• Catalog number
  bs-3253R
• Price
  Please ask
• Size
  0.1ml

• Long name
  LRP6 (Ser1490) Primary Polyclonal Antibody
• Also known as
  LRP6 (Ser1490) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  LRP6 Ser1490
• Specificity
  This is a highly specific antibody against LRP6 Ser1490.
• Modification s
  Phosphorylation
• Modification site s
  Ser1490
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  1470-1520/1613
• Subcellular location
  Cytoplasm
• Source
  KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490
• Gene ID number
  4040
• Swiss Prot
  O75581
• Tested Applications
  IHC-P, IF(IHC-P), IF(ICC)
• Recommended dilutions
  IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
• Cross reactivity
  Human, Mouse
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  ADCAD2; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LRP6   Ser1490  
• Gene symbol
  LRP6
• Short name
  Anti-LRP6 Ser1490
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  LRP6 (Ser1490) Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  low density lipoprotein receptor-related protein 6, ADCAD2, LRP6 and IDBG-20075 and ENSG00000070018 and 4040, coreceptor activity involved in Wnt receptor signaling pathway, Cell surfaces, Lrp6 and IDBG-194033 and ENSMUSG00000030201 and 102642234,16974, LRP6 and IDBG-639434 and ENSBTAG00000011761 and 536328

Gene info

• Identity
  HGNC:6698
• Gene
  LRP6
• Long gene name
  LDL receptor related protein 6
• Synonyms gene name
  • low density lipoprotein receptor-related protein 6
• Synonyms
  • ADCAD2
• GenBank acession
  • AF074264
• Locus
  12p13.2
• Discovery year
  1998-04-07
• Entrez gene record
  4040
• Pubmed identfication
  • 9704021
• Classification
  • Low density lipoprotein receptors
• VEGA ID
  OTTHUMG00000168540

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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