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Alternative_name
(8S,10S)-8-acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-1,6,8,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione; Carminomycin I
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Description
Carubicin is an anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Also acts as an inducer of apoptosis that targets Golgi complex in clear cell renal carcinoma cells.
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CAS Number
50935-04-1
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Structure Available
Yes
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Molecular Formula
C₂₆H₂₇NO₁₀
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Molecular Weight
513.49
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO
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Handling
Protect from air and light
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Tag Line
An anthracycline antineoplastic antibiotic
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Storage Condition
-20°C
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Shipping Condition
Gel Pack
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Shelf Life
36 months
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PubChem CID
443831
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SMILES
CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5O)O)(C(=O)C)O)N)O
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InChi
InChI=1S/C26H27NO10/c1-9-21(30)13(27)6-16(36-9)37-15-8-26(35,10(2)28)7-12-18(15)25(34)20-19(23(12)32)22(31)11-4-3-5-14(29)17(11)24(20)33/h3-5,9,13,15-16,21,29-30,32,34-35H,6-8,27H2,1-2H3/t9-,13-,15-,16-,21+,26-/m0/s1
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InChi Key
XREUEWVEMYWFFA-CSKJXFQVSA-N
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MSDS Available
Yes