Linsitinib Free base

Linsitinib Free base is available 4 times from Biovision labs

2294-5 | Linsitinib, Free basesize: 5 mg | 313.25 USD

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2294-25 | Linsitinib, Free basesize: 25 mg | 711.94 USD

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2294-5 | Linsitinib, Free base for cell activationsize: 5 mg | 211.87 USD

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2294-25 | Linsitinib, Free base for cell activationsize: 25 mg | 645.87 USD

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  • Alternate Name/Synonyms
    (1S,3S)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol; OSI-906; OSI 906AA
  • Appearance
    White to off-white solid
  • Formulation
    N/A
  • CAS Number
    867160-71-2
  • Peptide sequence
    No
  • Molecular Formula
    C₂₆H₂₃N₅O
  • Molecular Weight
    421.49
  • Purity
    ≥99% by HPLC
  • Solubility/Reconstitution Instructions
    DMSO (~50 mg/ml) or Ethanol (~3 mg/ml)
  • Handling
    Protect from air and light
  • Tagline
    A potent, dual insulin-like growth factor-1 receptor (IGF-1R)/insulin receptor (IR) kinase inhibitor.
  • Storage Temp.
    -20 ̊C
  • Shipping Conditions
    gel pack
  • Shelf Life
    36 months
  • MDL Number
    MFCD12912153
  • PubChem CID
    11640390
  • Category
    Biochemicals
  • Description
    A potent, small-molecule dual insulin-like growth factor-1 receptor (IGF-1R)/insulin receptor (IR) kinase inhibitor. Inhibits IGF-1R and IR kinases with IC₅₀ values of 35 nM and 75 nM, respectively. Linsitinib selectively blocks the autophosphorylation of both human IGF-1R and IR, inhibits the proliferation of a variety of tumor cell lines in vitro, and displays robust in vivo anti-tumor efficacy in an IGF-1R-driven xenograft model when administered orally.
  • CAS number
    867160-71-2
  • Molecular weight
    421.49
  • Other name
    (1S,3S)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol; OSI-906; OSI 906AA
  • Molecular formula
    C₂₆H₂₃N₅O
  • Physical appearance
    White to off-white solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥99% by HPLC
  • Reconstitute instructions
    DMSO (~50 mg/ml) or Ethanol (~3 mg/ml)
  • Storage condition
    -20 ̊C
  • Shipping condition
    gel pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from air and light
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