LIN28A (55CT58.12.1) Monoclonal Antibody

• Catalog number
  bsm-51022M
• Price
  Please ask
• Size
  0.1ml

• Long name
  LIN28A (55CT58.12.1) Monoclonal Antibody
• Also known as
  LIN28A (55CT58.12.1) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  LIN28A
• Specificity
  This is a highly specific antibody against LIN28A.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  55CT58.12.1
• Source
  LIN28A recombinant protein is used to produce this monoclonal antibody.
• Gene ID number
  79727
• Swiss Prot
  Q9H9Z2
• Tested Applications
  WB, IHC-P, IF
• Recommended dilutions
  WB(1:200~2000) , IHC-P(1:50~200), IF(1:10~50)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs (PubMed:19703396) (PubMed:22118463) (PubMed:22898984). Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (By similarity).
• Purification method
  Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A; Protein lin-28 homolog A; Zinc finger CCHC domain-containing protein 1; LIN28A
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  LIN28A   55CT58   Monoclonal  
• Gene symbol
  LIN28A
• Short name
  Anti-LIN28A
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG) κ
• Alternative name
  LIN28A (55CT58.12.1) Monoclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:15986
• Gene
  LIN28A
• Long gene name
  lin-28 homolog A
• Synonyms gene
  • LIN28
• Synonyms gene name
  • lin-28 homolog (C. elegans)
• Synonyms
  • LIN-28
  • FLJ12457
  • ZCCHC1
  • CSDD1
• GenBank acession
  • AF521099
• Locus
  1p36.11
• Discovery year
  2003-07-21
• Entrez gene record
  79727
• Pubmed identfication
  • 12798299
• RefSeq identity
  • NM_024674
• Classification
  • Zinc fingers CCHC-type
• VEGA ID
  OTTHUMG00000003550

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products