LIMKi 3

• Catalog number
  B1095-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide ; BMS 5
• Description
  LIMKi 3 is a potent, and cell-permeable inhibitor of LIMK1 (IC₅₀ = 7 nM) and LIMK2 (IC₅₀ = 8 nM) and inhibits coflin phosphorylation in MDA-MB-231 breast cancer cells without affecting tubulin polymerization or inducing cytotoxicity. It also reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.
• CAS Number
  1338247-35-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₇H₁₄Cl₂F₂N₄OS
• Molecular Weight
  431.29
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>40mg/ml)
• Handling
  Protect from air and light
• Tag Line
  LIMKi 3 is a potent inhibitor of LIMK1 and LIMK2
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  56965901
• PubChem CID Link
• SMILES
  CC(C)C(=O)NC1=NC=C(S1)C2=CC(=NN2C3=C(C=CC=C3Cl)Cl)C(F)F
• InChi
  InChI=1S/C17H14Cl2F2N4OS/c1-8(2)16(26)23-17-22-7-13(27-17)12-6-11(15(20)21)24-25(12)14-9(18)4-3-5-10(14)19/h3-8,15H,1-2H3,(H,22,23,26)
• InChi Key
  IVUGBSGLHRJSSP-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  LIMKi  
• Short name
  LIMKi 3
• Alternative name
  LIMKi 3

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