LFA3 Antibody

• Catalog number
  RP1106
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  LFA3
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, mouse, rat
• Analyses
  WB,IHC-P
• Immunogen
  E. coli-derived human LFA3 recombinant protein (Position: F29-R215).
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the LFA3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The LFA3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. It binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to. The LFA3 gene is mapped to chromosome 1p13, which is the same location as CD2.
• Related articles
  1. Barbosa, J. A., Mentzer, S. J., Kamarck, M. E., Hart, J., Biro, P. A., Strominger, J. L., Burakoff, S. J. Gene mapping and somatic cell hybrid analysis of the role of human lymphocyte function-associated antigen-3 (LFA-3) in CTL-target cell interactions. J. Immun. 136: 3085-3091, 1986. 2. Sewell, W. A., Palmer, R. W., Spurr, N. K., Sheer, D., Brown, M. H., Bell, Y., Crumpton, M. J. The human LFA-3 gene is located at the same chromosome band as the gene for its receptor CD2. Immunogenetics 28: 278-282, 1988. 3. Wang, J., Smolyar, A., Tan, K., Liu, J., Kim, M., Sun, Z. J., Wagner, G., Reinherz, E. L. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Cell 97: 791-803, 1999.
• Gene Name
  CD58
• Protein Name
  Lymphocyte function-associated antigen 3
• Gene Full Name
  CD58 molecule
• Synonyms
  AG3 | CD58 | CD58 antigen | CD58 molecule | LFA 3 | LFA-3 | LFA3 | P19256
• Uniprot ID
  P19256
• Entrez GeneID
  965
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LFA3  
• Gene symbol
  CD58
• Short name
  LFA3 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  LFA3 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1688
• Gene
  CD58
• Long gene name
  CD58 molecule
• Synonyms gene
  • LFA3
• Synonyms gene name
  • CD58 antigen, (lymphocyte function-associated antigen 3)
• GenBank acession
  • BC005930
• Locus
  1p13.1
• Discovery year
  1989-04-06
• Entrez gene record
  965
• Pubmed identfication
  • 9510189
• RefSeq identity
  • NM_001779
• Classification
  • CD molecules
  • Ig-like cell adhesion molecule family
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000022749

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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