Leukadherin 1 for cell activation

Leukadherin 1 for cell activation is available 2 times from Biovision labs

2059-50 | Leukadherin-1 for cell activationsize: 50 mg | 512.69 USD

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2059-10 | Leukadherin-1 for cell activationsize: 10 mg | 174.03 USD

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  • Description
    A novel small molecule agonist of integrin CD11b/CD18 (also known as Mac-1). LA1 increases the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils, which results in decreased chemotaxis and transendothelial migration. LA1 also decreases leukocyte recruitment and reduced arterial narrowing after injury in rats. In addition, compared to a known integrin antagonist IMB-10, LA1 better preserves kidney function in a mouse model of experimental nephritis.
  • Peptide sequence
    N/A
  • CAS number
    344897-95-6
  • Molecular weight
    421.49
  • Category
    Biochemicals
  • Other name
    4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid; LA1
  • Molecular formula
    C₂₂H₁₅NO₄S₂
  • Physical appearance
    Crystalline solid
  • Supplied with
    N/A
  • Is this a salt?
    N/A
  • Is it cell-permeable?
    Yes
  • Purification
    ≥97% by HPLC
  • Reconstitute instructions
    DMSO (10 mM)
  • Storage condition
    -20°C
  • Shipping condition
    gel pack
  • Maximum time for storage
    24 months
  • Storage instructions
    Protect from air and light
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    Leukadherin-1 for activation
  • Technique
    activation
  • Alternative name
    Leukadherin-1 to measure cellular activation
  • Tissue
    cell
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