Lestaurtinib, FLT3, TrkA kinase inhibitor

• Catalog number
  SIH-460-5MG
• Price
  Please ask
• Size
  5 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  111358-88-4
• Description
  FLT3, TrkA kinase inhibitor
• Molecular weight
  439,5 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
• Other name
  KT5555, CEP-701, (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C26H21N3O4
• Origin
  Synthetic
• Purity pourcentage
  ≥98% (HPLC)
• Soluble in
  Soluble to 100 mM in DMSO and to 25 mM in ethanol
• Physical appearance
  White powder
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  126565
• Scientific context
  Lestaurtinib is potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor. Specifically, it prevents STAT5 phosphorylation. Lestaurtinib exhibits antiproliferative activity in vitro.
• Bibliography
  1. Weisel K.C., et al. (2007) Ann. NY Acad. Sci. 1106: 190–196. 2. Hexner E.O., et al. (2008) Blood. 111(12): 5663–5671.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Lestaurtinib (SIH-460), a FLT3/ TrkA kinase inhibitor. CAS #: 111358-88-4. Molecular Formula: C26H21N3O4. Molecular Weight: 439.5 g/mol. Chemical structure of Lestaurtinib, a FLT3/ TrkA kinase inhibitor (SIH-460). CAS # 111358-88-4. Molecular Formula: C26H21N3O4.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.005
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Lestaurtinib   FLT3   TrkA   kinase   inhibitor  
• Gene symbol
  FLT3
• Short name
  Lestaurtinib, FLT3, TrkA kinase inhibitor
• Alternative name
  Lestaurtinib, fms-related tyrosine kinase 3, TrkA phosphorylation catalyst suppressor
• Alternative to gene target
  fms-related tyrosine kinase 3, CD135 and FLK-2 and FLK2 and STK1, FLT3 and IDBG-19891 and ENSG00000122025 and 2322, transferase activity, nuclei, Flt3 and IDBG-209045 and ENSMUSG00000042817 and 14255, BT.28173 and IDBG-630678 and ENSBTAG00000018572 and 512700

Gene info

• Identity
  HGNC:3765
• Gene
  FLT3
• Long gene name
  fms related receptor tyrosine kinase 3
• Synonyms gene name
  • fms-related tyrosine kinase 3
  • fms related tyrosine kinase 3
• Synonyms
  • STK1
  • FLK2
  • CD135
• GenBank acession
  • U02687
• Locus
  13q12.2
• Discovery year
  1990-07-30
• Entrez gene record
  2322
• Pubmed identfication
  • 8394751
• Classification
  • Immunoglobulin like domain containing
  • Receptor tyrosine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000016646
• Locus Specific Databases
  • LRG_457

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