LDN193189 for cell activation

LDN193189 for cell activation is available 2 times from Biovision labs

1995-25 | LDN193189 for cell activationsize: 25 mg | 793.95 USD

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1995-5 | LDN193189 for cell activationsize: 5 mg | 273.38 USD

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  • Description
    Cell-permeable. LDN193189 is a small molecule inhibitor of BMP type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively).It only weakly inhibits ALK4, ALK5, and ALK7. LDN193189 functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms. LDN-193189 has been used to reduce ectopic ossification in a mouse model. The role of BMP2 signals in the growth and angiogenesis of non-small-cell lung carcinoma (NSCLC) also suggest LDN-193189 may be a potent inhibitor of lung tumors.
  • Peptide sequence
    N/A
  • CAS number
    1062368-24-4 (free base)
  • Molecular weight
    442.94
  • Category
    Biochemicals
  • Other name
    6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine, hydrochloride; DM-3189
  • Molecular formula
    C₂₅H₂₂N₆.HCl
  • Physical appearance
    Yellow solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥97% by HPLC
  • Reconstitute instructions
    DMSO (10 mM)
  • Storage condition
    -20°C
  • Shipping condition
    gel pack
  • Maximum time for storage
    24months
  • Storage instructions
    Protect from light and moisture
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    LDN193189 for activation
  • Technique
    activation
  • Alternative name
    LDN193189 to measure cellular activation
  • Tissue
    cell
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