LATS2 (Ser83) Antibody

• Catalog number
  bs-4082R
• Price
  Please ask
• Size
  0.1ml

• Long name
  LATS2 (Ser83) Primary Polyclonal Antibody
• Also known as
  LATS2 (Ser83) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  LATS2 Ser83
• Specificity
  This is a highly specific antibody against LATS2 Ser83. This phosphorylation site is homologous to that of Ser82 in Mouse and Ser83 Rat.
• Modification s
  Phosphorylation
• Modification site s
  Ser83
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  70-100/1088
• Subcellular location
  Cytoplasm, Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human LATS2 around the phosphorylation site of Ser83
• Gene ID number
  26524
• Swiss Prot
  Q9NRM7
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  KPM; Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase; LATS2
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LATS2   Ser83  
• Gene symbol
  LATS2, LATS2-AS1
• Short name
  Anti-LATS2 Ser83
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  LATS2 (Ser83) Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  LATS, large tumor suppressor, homolog 2 (Drosophila), LATS2 and IDBG-13987 and ENSG00000150457 and 26524, transferase activity, nuclei, Lats2 and IDBG-168883 and ENSMUSG00000021959 and 50523, LATS2 and IDBG-631161 and ENSBTAG00000014406 and

Gene info

• Identity
  HGNC:6515
• Gene
  LATS2
• Long gene name
  large tumor suppressor kinase 2
• Synonyms gene name
  • LATS (large tumor suppressor, Drosophila) homolog 2
  • LATS, large tumor suppressor, homolog 2 (Drosophila)
• GenBank acession
  • AB028019
• Locus
  13q12.11
• Discovery year
  1999-12-07
• Entrez gene record
  26524
• Pubmed identfication
  • 10673337
• Classification
  • AGC family kinases
• VEGA ID
  OTTHUMG00000016531

Gene info

• Identity
  HGNC:39912
• Gene
  LATS2-AS1
• Long gene name
  LATS2 antisense RNA 1
• Synonyms gene name
  • LATS2 antisense RNA 1 (non-protein coding)
• Locus
  13q12.11
• Discovery year
  2011-04-11
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000016527

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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