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Category
Proteins & Peptides
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Long description
Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.
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Antibody come from
Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant PI-9 produced in P.pastoris and mouse myeloma cells.
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Other description
Provided as solution in phosphate buffered saline with 0.05% sodium azide.
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Clone
not specified
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Antigen antibody binding interaction
Lass6 - Blocking Peptide
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Antibody is raised in
Rabbit
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Antibody s reacts with
Human
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Antibody s reacts with these species
This antibody doesn't cross react with other species
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Antibody s specificity
No Data Available
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Application
Western Blot
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Antibody s suited for
Antibody can be used for Flow cytometry, Immunohistochemistry (frozen & paraffin*), Western Blot. Immunohistochemistry requires antigen retrieval using heat treatment methods prior to staining of paraffin sections. Optimal concentration should be evaluated by serial dilutions. _x000B_
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Storage
-20ºC
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Relevant references
1. Hirst CE, Buzza MS, Sutton VR, Trapani JA, Loveland KL and Bird PI (2001). Perforin-independent expression of granzyme B and proteinase inhibitor 9 in testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction. Hum Mol Reprod 7, 1133-1142._x000B__x000B_2. Hirst CE, Buzza MS, Bird CH, Warren HS, Cameron PU, Zhang M, Ashton-Rickardt, and Bird PI (2003). The Intracellular Granzyme B Inhibitor, Proteinase Inhibitor 9, Is Up-Regulated During Accessory Cell Maturation and Effector Cell Degranulation, and Its Overexpression Enhances CTL Potency. Jnl of Immunology, 2003, 170: 805-815_x000B_
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Protein number
see ncbi
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Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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Test
You can block the antibody by the specific target amino acid sequence of peptide.
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Properties
blocking peptide
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Description
Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.
