Lactacystin, Proteasome inhibitor
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Catalog number
SIH-327-1MG
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Price
Please ask
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Size
1 mg
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Stock availabilitIn Stock
In Stock
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CAS number
133343-34-7
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Description
Proteasome inhibitor
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Molecular weight
376,4 g/mol
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Primary research fields
Cancer, Apoptosis, Cancer Growth Inhibitors, Proteasome Inhibitors
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Other name
(2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C15H24N2O7S
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in DMSO, Water or Ethanol
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Physical appearance
White Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
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PubChem number
6610292
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Scientific context
Specific inhibitor of three proteolytic activities of the proteasome. Chymotrypsin-like activity is inhibited most potently followed by trypsin-like activity. Peptidyl-glutamyl peptide hydrolytic activity is relatively weak.
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Bibliography
1. Omura S., et al. (1991) J. Antibiot. 44: 113. 2. Fenteany G., et al. (1995) Science 268: 726
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Release date
6-Jun-2012
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Lactacystin (SIH-327), a Proteasome inhibitor. CAS #: 133343-34-7. Molecular Formula: C15H24N2O7S. Molecular Weight: 376.4 g/mol. Chemical structure of Lactacystin, a Proteasome inhibitor (SIH-327). CAS # 133343-34-7. Molecular Formula: C15H24N2O7S.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.001
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Short name
Lactacystin, Proteasome inhibitor
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Alternative name
Lactacystin, protein degradation aggregate suppressor
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