L-Histidine 7-amido-4-methylcoumarin

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Cas number

191723-64-5
Chemical s molecular weight

312.32
Chemical s main applications

L-Histidine 7-amido-4-methylcoumarin is an enzyme substrate. Substrates of glycosidases, phosphatases and esterases are commonly employed in microbiology, food/water, environmental and ELISA testing. Assays of peptidases are more important in clinical enzyme assays and AMC is the fluorophore employed in most of these substrates. AMC is extremely versatile since the carboxy-terminus of any amino acid or peptide can be linked to it. Most enzymes are tolerant towards the AMC structure. Typically, kinetics of enzyme reactions remain undisturbed and few inhibitory effects are observed. Due to the low basicity of the amino group, AMC is not subject to acid base equilibrium at physiological pH. Therefore, assays using AMC substrates are rather tolerant of pH.
Other name

(αS)-α-Amino-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-1H-Imidazole-4-propanamide
Chemical s formula

C16H16N4O3
Physical properties

No Data Available
Melting temperature

No Data Available
Boiling temperature

No Data Available
Chemical s soluble in

No Data Available
Stability conditions

No Data Available
Storage

No Data Available
Chemical s specifications

Gene target

L-Histidine 7-amido-4-methylcoumarin
Gene symbol

MIR1302-4, PIRC18, PIRC16, SNORD114-4, MIR941-4, IGKV2OR2-4, ANKRD20A12P, PIRC17
Short name

L-Histidine 7-amido-4-methylcoumarin
Alternative name

L-Histidine 7-amido-4-methylcoumarin

Identity

HGNC:5809
Gene

IGKV2OR2-4
Long gene name

immunoglobulin kappa variable 2/OR2-4 (pseudogene)
Synonyms gene name
- immunoglobulin kappa variable 2/OR2-4
- immunoglobulin kappa variable 2/OR2-4 pseudogene
Synonyms
- IGKV2/OR2-4
GenBank acession
- X51883
Locus

2q11.2
Discovery year

2000-04-18
Entrez gene record

28858
Pubmed identfication
- 2111145
Classification
- Immunoglobulin kappa (IGK) orphons